Science Weekly

When the water in Flint, Michigan, became contaminated with dangerous levels of lead, Dr Siddhartha Roy, then a third year PhD student, was part of the team of scientists who publicly contradicted state and federal claims that it was safe. He became a local hero until a new piece of research challenged the idea that children in Flint had been left permanently brain damaged by the crisis. His adherence to the evidence, no matter who it offended, has earned him the 2026 Maddox prize, which recognises individuals who stand up for science and evidence, despite challenges or hostility. He tells Ian Sample how he reflects on his experience in Flint, and why he lost friends as a result of his work there. Help support our independent journalism at https://www.theguardian.com/sciencepod

As one of the world’s leading forensic anthropologists, Dame Sue Black has acted as an expert witness in a myriad of high-profile criminal cases. Her work has taken her from the lab to active war zones and the aftermath of natural disasters to identify victims’ bodies. Speaking to Ian Sample, the professor explains why standing up in front of a judge and jury has been one of the more terrifying parts of her career, the reputational risk of presenting evidence in court and what the future of forensic science could look like. Help support our independent journalism at https://www.theguardian.com/sciencepod

Perimenopause has become a hot topic, with celebrities sharing their experiences and doctors offering tips and advice online. But despite the benefits of growing awareness, a rising number of women are now encountering misinformation about treatments such as HRT. Madeleine Finlay hears from Dr Paula Briggs, a consultant in sexual and reproductive health, about why experts have raised the alarm. Science correspondent Nicola Davis gives the facts on symptoms, tests and treatments. Help support our independent journalism at https://www.theguardian.com/sciencepod

You Can See Everything, a documentary about the disgraced biotech company founder Elizabeth Holmes, has enjoyed a record-breaking opening in the US. It is a testament to how fascinated we remain by the convicted fraudster, but what is behind the enduring appeal? US technology editor Blake Montgomery tells Madeleine Finlay why Holmes continues to fascinate us, and reflects on whether the Theranos scandal has had a permanent impact on Silicon Valley. Help support our independent journalism at https://www.theguardian.com/sciencepod

In his annual speech on threats to the nation, Sir Ken McCallum, the head of the UK’s intelligence service, MI5, warned that AI had the potential to ‘change the stakes’ on existing and even new bioweapons. To find out why, and how, Ian Sample speaks to Dr Tom Inglesby, director of the Johns Hopkins Center for Health Security and the Bloomberg School of Public Health. He explains what has governments so worried and what measures could be put in place to reduce the risks. Help support our independent journalism at https://www.theguardian.com/sciencepod

Workers have always been monitored by their bosses, first through output targets, and then via computer software labelled ‘bossware’. But AI is transforming the capabilities of these systems, processing huge volumes of data to provide minute-by-minute accounts of activity, and productivity. To find out more, Ian Sample hears from UK technology editor Robert Booth. He explains which sectors are adopting this approach, why they are doing it, and how it could end up being counterproductive.. Help support our independent journalism at https://www.theguardian.com/sciencepod

US defence secretary Pete Hegseth’s plan to livestream the execution of Nidal Malik Hasan has incurred condemnation from human rights groups and politicians on all sides. But according to Coltan Scrivner, an author and psychologist at Arizona State University and expert on morbid curiosity, people are still likely to watch in large numbers. He explains why we are drawn to dark and disturbing content, and Madeleine Finlay tells Ian Sample how consuming this kind of material can harm observers’ mental health. Help support our independent journalism at https://www.theguardian.com/sciencepod

This year’s Nobel prizes in chemistry, physics and physiology or medicine have celebrated work that has been used to develop countless drugs and transform modern medicine, allowed physicists to observe one of the most mysterious particles, and provided a tool that could act as an on/off switch for brain cells. To find out more, Madeleine Finlay talks to our science editor, Ian Sample, and correspondents Nicola Davis and Linda Geddes. Help support our independent journalism at https://www.theguardian.com/sciencepod

Several hospitals in eastern Russia are under quarantine after a lab worker fell ill at a plague research centre following a reported accident and died. Russia’s health watchdog has said Darya Shipilova, 28, died of ‘pneumonia of unknown aetiology’, but there is speculation about a possible plague infection. Science Weekly co-host Madeleine Finlay tells Lucy Hough, the host of Today in Focus: The Latest, how concerned we should be. Help support our independent journalism at https://www.theguardian.com/sciencepod

The sleep disorder has been the butt of jokes and a comedic plot point, but the reality of living with narcolepsy is anything but funny. Things could be about to change for people with the condition though, after the US Food and Drug Administration (FDA) approved the first ever drug to treat narcolepsy itself, rather than just its symptoms. Madeleine Finlay tells Ian Sample how the scientific breakthrough came about, and Julie Flygare, who has narcolepsy and founded the non-profit Project Sleep, explains what it is like to live with the condition and how the drug could be gamechanger. Help support our independent journalism at https://www.theguardian.com/sciencepod

Madeleine Finlay hears from Steve Ramirez, an associate professor of psychological and brain sciences at Boston University, whose book How to Change a Memory was shortlisted for this year’s Royal Society Trivedi science book prize. He explains how scientists have been able to locate memories in the brains of rodents, trigger them artificially and even remove them, and reveals what the practical applications of this science could one day be for humans.. Help support our independent journalism at https://www.theguardian.com/sciencepod

Our use of cleaning products has increased since the pandemic, but do we understand what they could be doing to our health? The journalist Rebecca Seal recently wrote for the Guardian about the potential impacts of the many chemicals we now use in our homes. She tells Madeleine Finlay how social media has also played a role in transforming our cleaning habits, why the impact of indoor air pollution is so hard to study, and what the current evidence is that cleaning products may be causing harm. Help support our independent journalism at https://www.theguardian.com/sciencepod

Madeleine Finlay sits down with her co-host and Guardian science editor, Ian Sample, to discuss three science stories from the week, including a study that offers a clue in the age-old debate about whether sex differences are present from birth or a product of socialisation. Also on the agenda is the super El Niño, which is predicted to lead to 450,000 deaths in the next six months, and an answer to why the UK’s meningitis outbreak earlier this year was so big.. Help support our independent journalism at https://www.theguardian.com/sciencepod

As diet trends proliferate on social media, it can be hard to work out which are backed by science and which should be ignored. From paleo to keto, raw food to intermittent fasting, each attracts a tribe of ardent followers. Now Daniel Lieberman, professor of biological sciences at Harvard University, has written a book to try to cut through the noise. In Fed Up, he uses his background as an evolutionary anthropologist to scrutinise the evidence, turning himself into a guinea pig in the process and trying various diets. In this podcast, he tells Ian Sample which one has remained part of his routine. Help support our independent journalism at https://www.theguardian.com/sciencepod

In early September, OpenAI announced it had solved a major mathematics problem that has stumped humans for nearly a century. The news left mathematicians reeling, and many expressed concern over what will be left for humans as AI becomes ever more adept at unravelling complex problems. Now 25 recipients of the Fields medal – often called the Nobel prize for maths – have signed an open letter expressing their fears of a ‘severe misalignment’ between AI companies and their field. To find out how AI is likely to upend maths – and how mathematicians might respond – Ian Sample speaks to Colva Roney-Dougal, professor of pure mathematics at the University of St Andrews. Help support our independent journalism at https://www.theguardian.com/sciencepod

Collagen powders, gummies and pills have boomed in popularity in recent years boosted by claims that they smooth wrinkles, promote glossy hair and help with joint pain. Amid the noise it can be hard to figure out whether there’s any actual science behind the promise of looking younger for longer. Luckily Dr Xand van Tulleken has spent the past three years writing Make me well: a quest to understand the confusing world of wellness, and his chapter on collagen dives deep into the evidence. He tells Madeleine Finlay what collagen does in the body, how we can get it without splashing out on expensive supplements, and why getting to the truth behind wellness claims can be so hard. Help support our independent journalism at https://www.theguardian.com/sciencepod

In this episode of Science Weekly, recorded in front of an audience at the London podcast festival on 3 September, Ian Sample hears from Michael Safi, the host of the Guardian’s chart-topping podcast about artificial intelligence, Black Box. In series two, Black Box: the chatbots, Michael meets people who have become convinced they have made scientific breakthroughs, cured diseases or invented new technologies using AI chatbots. Ian, Michael and Science Weekly’s co-host Madeleine Finlay explore the phenomenon labelled ‘AI psychosis’ and ask what it reveals about a technology now used by more than a billion people. Help support our independent journalism at https://www.theguardian.com/sciencepod

For decades physicists have been puzzling over the enigma of dark matter. We think it makes up 85% of the matter in the universe, but the mysterious substance cannot be seen or detected, and we know about it mainly through observations of the gravitational effects it has on other things. But now scientists believe they may be a step closer to detecting it. Science editor Ian Sample explains to Madeleine Finlay why, if confirmed, the finding could completely transform our understanding of the universe. And Dr Samuel Eriksen, senior research associate at the University of Bristol, and first author of the research paper, explains how the finding has been received in the physics community. Help support our independent journalism at https://www.theguardian.com/sciencepod

Who’s more likely to steal sweets from a child? According to science, it’s the rich. A study seemingly confirming our suspicions about the moral behaviour of the wealthy was one of the winners of the 2026 Ig Nobel prizes, which honour research that makes you laugh and then think. Science editor Ian Sample tells Madeleine Finlay what the researchers think could be behind the phenomenon, and they explore some of the other awards, including one for a surprising quality we look for in our friends and another for a biomechanical definition of kissing. Help support our independent journalism at https://www.theguardian.com/sciencepod

From the Guardian Investigates team: Across the world, hundreds of people have come to believe they have made extraordinary scientific discoveries with AI chatbots such as ChatGPT, Claude and Gemini. Others say their AI has ‘awakened’ or is leading them to a higher spiritual realm. The Guardian journalist Michael Safi begins investigating a phenomenon labelled ‘AI psychosis’, travelling to the US to meet two people who have been on weird journeys with their chatbots. Help support our independent journalism at https://www.theguardian.com/sciencepod