Podcast

The Beyond Tomorrow Podcast with Julian Issa

Life Sciences, Science

The future feels exciting but a little scary. We're here to help guide you through it.

How?

1. Building stronger, more abundant mindsets.

2. Shining a spotlight on the technologies of tomorrow.

3. Identifying the latest longevity & health protocols.

Health, longevity, human potential and AI.

It's great to have you here.

Julian

Episodes
112
Releases
Twice a week
Typical length
56 min
On air since
2025
Latest episode
9 hours ago

Episodes

112 episodes, newest first

  1. Beyond Tomorrow New Trailer Trailer

    Show notes

    I have a strong conviction that the next chapter in the human story will bring incredible opportunity and abundance to us all if we take the right steps. At Beyond Tomorrow, we want to help steward that transition. After all, our mission is to help build a world where anyone can flourish. Thank you for being part of our journey

    1 min
  2. AI EXPERTS REVEAL: It’s Too Late! We Can't Stop What's Coming

    Show notes

    Everyone agrees we can’t pause AI. So what do we do instead?

    This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at http://agelessrx.com/beyond-tomorrow.

    Five people who think about AI for a living sit down for a rapid-fire debate, and the host throws a handful of big statements at them. First up: can we, or should we, pause AI? Almost nobody says yes, and the more interesting part is what they’d do instead. Some want to slow the frontier, some want to shape it as it goes, and one is trying to seed a beneficial AGI before someone else builds a worse one.

    From there the panel gets into recursive self-improvement and whether you can keep an AI’s goals stable, whether AI will widen the gap between rich and poor (and rich and poor countries), and who foots the bill when jobs disappear. Then comes the question of why experts and the public see AI so differently. Media, culture, and trust all take some blame. The last stretch compares a Manhattan Project approach with open, decentralized AGI, and everyone gets to say the one thing they think the world needs right now, plus a parting sentence.

    Key Takeaways

    •

    Nearly everyone calls a pause a non-starter: “AI” is too fuzzy to define, and a pause would just push work underground

    •

    Keeping an AI’s goals stable while it rewrites itself may be a solvable engineering problem, but not everyone agrees that’s even desirable

    •

    On inequality, the panel splits between “it’s already happening” and “the floor keeps rising”

    •

    Public opinion on AI is shaped more by culture and media than by the tech itself

    •

    The alternative to corporate control or a government Manhattan Project: open, decentralized AGI, in the spirit of Linux

    Meet the Panelists:

    •

    Ben Goertzel is the CEO of SingularityNET and Executive Chairman & Chief Scientist of BGI Labs who popularized the term “artificial general intelligence.” He’s building open-source, decentralized AGI.

    •

    Joscha Bach is a cognitive scientist and AI researcher focused on models of the mind and consciousness. He’s known for his philosophical takes on AI and ethics.

    •

    Kai Bickell is co-founder and Chief Ethics Officer of OpenBGI, working on a decentralized AI moral constitution. He’s also a survivor advocate honored by CHILD USA.

    •

    AJ Green is Executive Director of The AI Collective, the world’s largest AI nonprofit community.

    •

    Catherine McMillan is Chief Operating Officer of The AI Collective. She helps run its global network of chapters and events.

    ⏱ Timestamps

    00:00 Intro

    01:11 Can We Pause AI?

    08:50 Would AGI Actually Kill Us All?

    10:16 What’s Really Behind the Pause AI Debate

    13:40 How People Really Use AI Day to Day

    18:49 Can Self-Improving AI Stay Moral?

    20:46 How to Build a Moral AGI

    26:43 Will AI Widen the Wealth Gap?

    32:36 What a Beneficial Superintelligence Looks Like

    37:11 Will AI Destroy More Jobs Than It Creates?

    39:28 Society’s Bumpy Transition to AGI

    49:56 How the World Sees AI

    51:54 Why Culture Shapes Our View of AI

    01:03:04 Was AI Ever a Manhattan Project?

    01:10:50 Fear, Awareness, and the Public Knowledge Gap

    01:12:24 Who’s Funding the AI Narrative?

    01:15:26 The Case for Open, Decentralized AGI

    Connect with Ben

    Website: https://singularitynet.io/

    LinkedIn: https://www.linkedin.com/in/bengoertzel

    Connect with Kai

    Website: https://singularitynet.io/

    Connect with AJ

    Website: https://www.aicollective.com/

    LinkedIn: https://www.linkedin.com/in/aj-green-ai

    Connect with Catherine

    Website: https://catherine-mcmillan.com/

    LinkedIn: https://www.linkedin.com/in/catherine-r-mcmillan

    Connect with Joscha

    Website: http://bach.ai/

    LinkedIn: https://www.linkedin.com/in/joschabach/

    Connect with Julian

    Instagram: @thebeyondtomorrowpodcast/ @juliankissa

    LinkedIn: julian-issa

    X: @juliankissa

    Website: http://www.beyondtomorrowpodcast.com

    1 hr 30 min
  3. ROBOTICS PROFESSOR: "AI Is Becoming Self-Aware! Here’s the Biggest Danger!"

    Show notes

    Is “AI will destroy humanity” a real risk, or a story we tell ourselves because we haven’t done the hard engineering?

    This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at http://agelessrx.com/beyond-tomorrow.

    This conversation opens with a simple question to roboticist Hod Lipson, the mind behind Emo: does he feel like a villain? His answer is honest. He’s both excited and terrified, like someone being told an alien race is about to arrive and being asked whether to welcome them. From there, the discussion turns to why robot faces are so hard to build, and why he thinks the moment a robot genuinely smiles back at you will change how we connect with machines.

    Then it gets into the harder questions. Hod is firm that AI won’t wipe out humanity, and he’s challenged more than once on superintelligence, on who benefits from the fear, and on whether nested sandboxes and “AI cops” can really keep us safe. The conversation also explores what it means for a robot to be self-aware, robots that repair and even “eat” each other, why he worries about kids and students whose best friend is an AI, and how any of us finds meaning when machines can do almost everything. It closes with the best advice he’s ever been given.

    About Hod Lipson

    Hod Lipson is a roboticist and AI researcher who leads work on Emo, a robot focused on realistic facial expression and lip movement. His research spans robot self-awareness, self-repairing and self-reproducing robots, and AI in agriculture.

    ⏱ Timestamps

    00:00 Intro

    00:08 Do You Feel Like a Villain? The AI Disaster Question

    00:59 Robot Faces Are Next

    03:49 Why Do We Need a Robot Face?

    05:58 Robots That Look More Human-Like

    07:50 Are You Scared?

    08:42 “We Earned It” as a Human Race

    10:40 The Benefits of Developing AI

    15:07 Could AI Go Against Us?

    17:42 Regulation, Liability and the FDA Analogy

    20:00 Meet Emo

    23:56 How Will We Interact With Robots in 2030?

    27:00 Can a Humanoid Say No to You?

    29:24 Do We Lose Skills to Technology?

    32:24 Hod’s P(doom) Number: Zero

    34:54 AI Is Limited to a Small Part of Our Life

    37:42 Can You Switch Off All Robots?

    40:44 Is the Doomer Movement Marketing?

    43:40 Using AI to Make AI Safer

    46:23 Why AI Can’t Kill Us All

    50:07 China Leads in Robotics

    52:12 Can Robots Develop Awareness?

    58:12 The ChatGPT Moment for Robotics

    59:28 A Robot Best Friend for a Child?

    01:00:26 Would You Let a Robot Babysit?

    01:01:53 Self-Awareness in Robots

    01:03:42 The Weirdest Things People Will Do With Robots

    01:05:10 Building and Maintaining Robots: Robot Metabolism

    01:08:41 Exciting Possibilities With Physical Robots

    01:10:22 Humans Are Evolving Too

    01:13:04 The Pyramid of Needs: Finding Meaning

    01:17:35 The Best Piece of Advice

    01:18:58 If Tomorrow Was Your Last Day

    Connect with Hod:

    LinkedIn: https://www.linkedin.com/in/hod-lipson-4018189

    Website: https://www.hodlipson.com/

    YouTube: https://www.youtube.com/c/HodLipson1

    Books: https://www.amazon.com/stores/author/B008VGBM8E/allbooks

    Connect with Julian

    Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/ / https://www.instagram.com/juliankissa/

    LinkedIn: https://uk.linkedin.com/in/julian-issa

    X: https://x.com/juliankissa

    Website: http://www.beyondtomorrowpodcast.com

    Email: bookings@beyondtomorrowpodcast.com

    Watch the full episode on YouTube, or catch it on Spotify and Apple Podcasts. For more conversations from the edge of what's possible, sign up for updates here.

    1 hr 22 min
  4. BT Clip: Exercise Scientist on Weight Loss Drugs (Mike Israetel)

    Show notes

    Do we really know enough about GLP-1 drugs?

    Mike Israetel breaks down the risks and trade-offs, from anhedonia and calorie-deprived diets to cognitive distortion and the myth of a “zero-harm” default.

    Watch the full episode here: https://open.spotify.com/episode/4iHXkGzLvxSU87rzOHNvlq?si=361782122faa4ea9

    8 min
  5. 4 Longevity Legends Debate Each Other About Human Flourishing

    Show notes

    What if the fastest way to a longer life isn't a miracle drug, but a wartime mentality against aging?

    This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at http://agelessrx.com/beyond-tomorrow.

    Curious about quantum energy wellness? Check out Leela Quantum Tech. Check out https://leelaq.com/

    On this episode of Beyond Tomorrow, four heavyweights of the longevity field take a rapid-fire statement format and turn it into a real debate. Aubrey de Grey, Alex Zhavoronkov (Insilico Medicine), George Church (Harvard Medical School), Michael Ringel (Life Biosciences) argue over whether hype helps or hurts the field, and when longevity escape velocity, the point where damage is repaired faster than it accumulates, might actually arrive. Aubrey puts it at a 50/50 chance within 12 to 15 years. Alex says 20 to 50 years and doubts drugs alone can get there. Michael pushes back on the idea of infinite lifespans entirely, while George suggests we may already be gaining years without the evidence to prove it.

    From there the panel digs into the FDA's new interest in aging, why the TAME metformin trial never opened the floodgates, and whether AI will really shrink clinical timelines. George cites a gene therapy that reached a patient in seven months, while Alex, running many programs, argues that biology still moves at the speed of traffic. The back half covers biohacking and early adopters, the gap between everyday "longevity" and longevity biotechnology, the science of epigenetic reprogramming, what could happen by the XPRIZE Healthspan deadline in 2030, and what each panelist thinks the "ChatGPT moment" for longevity will look like.

    About the Panelists

    Aubrey de Grey has spent his entire career in the nonprofit sector, coined the term longevity escape velocity, and has been signed up with Alcor for cryonic preservation since 2002.

    Alex Zhavoronkov is the founder and CEO of Insilico Medicine, a public biotech company with a large pipeline of drug programs that uses AI to compress early discovery work.

    George Church is a Harvard Medical School geneticist and an optimist on gene therapy and exponential technologies, who argues that regulators embrace new technology and that trial parallelism could dramatically cut development time.

    Michael Ringel left a career at BCG to join Life Biosciences as chief operating officer, where he works on epigenetic restoration as a path to treating age-related disease and, ultimately, aging itself.

    ⏱ Timestamps

    00:00 Intro

    00:20 Is Hype Necessary for Longevity?

    02:49 When Hype Goes Too Far

    04:14 When Can Longevity Escape Velocity Happen?

    09:52 The FDA and Aging as a Focus Area

    19:49 Will AI Transform Longevity Research?

    24:04 Can AI Shorten Clinical Trials?

    26:57 AI Optimists vs. Skeptics

    28:38 Alex on Being the Field’s Biggest Skeptic

    32:00 Do Critics Need a Drug in the Clinic?

    35:24 When Criticism Does Harm

    36:45 Is Biohacking Hurting Longevity’s Credibility?

    46:57 What Could Be Possible by 2030?

    50:49 Optimism vs. Skepticism: Final Thoughts

    54:01 Cryonics

    54:36 The Longevity “ChatGPT Moment”

    Connect with Aubrey:

    X: https://x.com/aubreydegrey

    LinkedIn: https://www.linkedin.com/in/aubrey-de-grey-24260b

    Connect with Alex:

    X: https://x.com/biogerontology

    LinkedIn: https://www.linkedin.com/in/zhavoronkov

    Connect with George:

    LinkedIn: https://www.linkedin.com/in/george-church-2b86301

    Website: https://colossal.com/george-church/

    Connect with Michael:

    LinkedIn: https://www.linkedin.com/in/michael-ringel-b272a2

    Instagram: https://www.instagram.com/msringel/

    Connect with Julian

    Instagram: @thebeyondtomorrowpodcast/ @juliankissa

    LinkedIn: julian-issa

    X: @juliankissa

    Website: http://www.beyondtomorrowpodcast.com

    Email: bookings@beyondtomorrowpodcast.com

    1 hr 3 min
  6. BT Clip: Can We Escape The simulation? (Roman Yampolskiy)

    Show notes

    Are we living in a simulation?

    Dr. Roman Yampolskiy explains how scientists run experiments inside simulations, why boxing AI may not hold, and what it would mean if AI breaks out of its safe environment, or if humanity escapes its own.

    Watch the full episode here: https://open.spotify.com/episode/2R7oKzVSOWTR5079TYrZsg?si=7fd6c78a016a4b67

    10 min
  7. MIT Professor & AI Doomer Admits He Was WRONG (Ramesh Raskar)

    Show notes

    What happens when millions of people hand their lives to AI agents, and nobody has built the rules of the road?

    This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at http://agelessrx.com/beyond-tomorrow.

    MIT Media Lab professor Ramesh Raskar argues the real danger isn't the AI engine, it's agents with no governance. His case: decentralize AI so billions of people run their own agents, and build the licences, inspections and audit trails agents need, instead of trusting a few labs to make the engine safe. His P(doom) has fallen from 90% to under 10%.

    The conversation covers what an AI agent actually is, personal agents like Dot, Muse, Instinct and CC, the DRIVE framework for gradually trusting an agent, why there's no such thing as "zero-shot AGI," the OpenAI and Hugging Face incident, prompt injection, and the shift from an attention economy to an intention economy. One question runs through it all: can we get the benefits of AI agents without handing control to a handful of companies, or to the agents themselves? Ramesh's answer: don't just build better engines, build the roads, the rules and the governance.

    Key Takeaways

    •

    An agent is an LLM in a loop with tools: the LLM is the engine, the agent is the car, the internet is the road.

    •

    Build trust with DRIVE (Discover, Request, Instruct, Venture, Execute), and start with reversible tasks, no credit cards.

    •

    Decentralized agents shrink the blast radius, which is why Ramesh's P(doom) has dropped sharply.

    •

    Cost is the bottleneck: running an agent per user costs far more than serving a social media user, so expect revenue-share deals.

    •

    Prompt injection is the top risk because LLMs can't separate commands from content. Agents need licences, inspection stickers and audit trails.

    About Ramesh Raskar

    Ramesh Raskar is a professor at the MIT Media Lab, where he works on decentralized AI and the Internet of Agents. His research focuses on how personal AI agents can be built so power stays distributed instead of concentrated in a few companies.

    ⏱ Timestamps

    00:00 Intro

    00:00 Why AI Is Moving So Fast: The Intelligence Economy

    01:27 What Is an AI Agent, Really?

    04:00 Ramesh's P(Doom) Update

    05:46 Is Decentralized AI Safer Than Centralized AI?

    09:54 How to Use Personal AI Agents (Dot, Muse, Instinct)

    13:35 Will AI Agents Become the New Super App?

    17:44 The Agentic Web Explained

    20:14 Can Personal Superintelligence Exist?

    25:17 A Model That Learns How to Learn Everything

    29:19 AI Literacy: What to Do If You're Not Using AI

    31:16 From OpenClaw to Muse

    36:25 It's Not About Bigger Models, It's About Better Agents

    37:51 Road Safety Rules for AI Agents

    42:58 What a Safe Agentic World Looks Like

    44:23 Surfing the Web With AI Agents

    48:44 Voice, Screens or Taps? The Future of Agent Interfaces

    50:05 Where Will AI Agents Be in One Year?

    53:00 The Best Advice on Agent Autonomy

    55:12 The Best Things AI Agents Can Do Today

    57:12 Prompt Injection: The Command vs Content Problem

    01:03:35 If Tomorrow was Your Last Day...

    Resources & Mentions

    Muse (Meta): https://muse.ai

    Dots (OpenAI): https://siliconangle.com/2026/09/29/openai-launches-dots-always-on-ai-agents-in-chatgpt-with-their-own-cloud-computers/

    OpenClaw: https://openclaw.ai

    Hermes Agent (Nous Research): https://hermes-agent.nousresearch.com/docs/

    Connect with Ramesh:

    LinkedIn: https://www.linkedin.com/in/raskar

    MIT Media Lab: https://www.media.mit.edu/people/raskar/overview/

    Connect with Julian

    Instagram: @thebeyondtomorrowpodcast/ @juliankissa

    LinkedIn: julian-issa

    X: @juliankissa

    Website: http://www.beyondtomorrowpodcast.com

    Email: bookings@beyondtomorrowpodcast.com

    Watch the full episode on YouTube, or catch it on Spotify and Apple Podcasts. For more conversations from the edge of what's possible, sign up for updates here.

    1 hr 6 min
  8. BT Clip: Scientist Exposes The Dangers of AI Super Intelligence (Roman Yampolskiy)

    Show notes

    AI safety researcher Roman Yampolskiy breaks down his P(doom) estimate and why he believes artificial superintelligence could be a death sentence for humanity if development keeps moving this fast. His warning isn't anti-AI — it's a case for keeping AI as a tool we control, not a replacement for human judgment.

    Watch the full episode: https://open.spotify.com/episode/2R7oKzVSOWTR5079TYrZsg?si=302dfca33e9f4c04

    11 min
  9. Ex-DeepMind Scientist WARNS: Why We Still Can’t Trust Today’s AI

    Show notes

    Is "AI is dangerous" a warning, or the world's best marketing line?

    This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at http://agelessrx.com/beyond-tomorrow.

    On this episode of Beyond Tomorrow, I sit down with Thore Graepel, co-creator of AlphaGo and former researcher at Google DeepMind. I asked him straight up how close we are to superintelligence, and his answer surprised me: there won't be a single moment we can point to, and he argues human organizations like companies already count as a form of superintelligence. We get into why he thinks "AI will destroy humanity" is the biggest myth in the field, the near-term risks he does take seriously, and why I pushed him on the incentives behind the AI safety messaging coming from the labs.

    From there we go deep on his core technical argument: that today's transformers are black boxes that mix knowledge and reasoning in the same weights, and that scaling alone will never make them trustworthy. He lays out a different approach built on explicit beliefs, hypotheses and evidence, and I found it one of the clearest explanations of AI transparency I've heard. In the back half, we talk about his time at Altos Labs, why biology is a reality check for the "cure all disease in 10 years" claims, and his cell annealing theory of rejuvenation.

    Key Takeaways

    •

    Thore sees AI progress as a "jagged frontier," not a single superintelligence moment, and by his own definition, AGI is already here

    •

    He argues companies and institutions are already a form of superintelligence

    •

    His P(doom) is very low: extraordinary claims require extraordinary evidence, and he doesn't see it

    About Thore Graepel

    Thore Graepel is a computer scientist and AI researcher who recently left Google DeepMind, where he was a co-creator of AlphaGo and worked on multi-agent systems, reasoning and consciousness research. He has also spent time at Altos Labs, applying his machine learning and physics background to cellular rejuvenation, and writes about AI, reasoning and safety on Substack.

    ⏱ Timestamps

    00:00 Intro

    00:06 How Close Are We to Superintelligence?

    01:42 Are Human Organizations Already Superintelligent?

    02:56 Is Anyone Trying to Destroy Humanity?

    04:45 Near-Term Risks: Jobs and the Economy

    08:08 Why the Transition Will Be Hard

    10:06 Post-AGI Planning and the Case for Positive Futures

    14:35 Capability vs. Diffusion: The Train Driver Problem

    16:46 Optimization vs. Game Theory

    18:53 The Incentives Behind AI Safety Messaging

    22:26 What Is Thore's P(doom)?

    23:25 Why Transformers Are Black Boxes

    29:19 How Do We Build Safer, More Transparent AI?

    33:01 Separating Knowledge From Reasoning

    37:39 Safety vs. Capability and the Trust Ceiling

    39:45 Narrow AI vs. General AI

    44:02 Do You Believe in God?

    47:15 Consciousness and Whether LLMs Are Alive

    51:08 AlphaGo and Move 37

    58:29 Credit Assignment and Moral Reasoning

    01:04:31 Who Sets the Moral Guardrails?

    01:09:37 The AGI Race: US vs. China

    01:11:53 Longevity and Altos Labs

    01:16:01 The Biology Reality Check

    01:23:04 Pockets of Computability and AlphaFold

    01:26:05 Yamanaka Factors and Cell Annealing

    01:35:51 Will the Singularity Happen in Your Lifetime?

    01:36:49 Rapid Fire Questions with Thore

    01:41:35 Thore's Best Piece of Advice

    Resources & Mentions

    AlphaGo and AlphaFold (Google DeepMind)

    Thinking, Fast and Slow by Daniel Kahneman

    Altos Labs

    Stephen Wolfram's "pockets of computability"

    David Deutsch on simulation and the limits of experiment

    Thore's Substack

    Connect with Thore:

    Github: https://thoregraepel.github.io/

    LinkedIn: https://uk.linkedin.com/in/thoregraepel

    X: https://x.com/ThoreG

    Connect with Julian

    Instagram: @thebeyondtomorrowpodcast/ @juliankissa

    LinkedIn: julian-issa

    X: @juliankissa

    Website: http://www.beyondtomorrowpodcast.com

    Email: bookings@beyondtomorrowpodcast.com

    1 hr 43 min
  10. Dr Mike Israetel: ‘’ALMOST EVERY American Should Be On GLP-1s, Here’s Why!’’

    Show notes

    What if vanity was actually the smart way into a longer, healthier life?

    This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. Their mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at agelessrx.com/beyond-tomorrow.

    On this episode of Beyond Tomorrow, Dr. Mike Israetel breaks down what's actually happening in his own bloodstream: 5mg/week of tirzepatide year-round, plus retatrutide during fat-loss phases, and why he thinks “GLP-2” is a gray-market marketing term with no basis in real receptor biology.

    He walks through the non-weight-loss case for these drugs, reduced systemic and neural inflammation, better glucose control, emerging anti-cancer data, and a documented drop in addictive behaviors from gambling to alcohol to cigarettes, before getting honest about the tradeoffs: undernutrition, anhedonia, and a long-term data set that, by his own admission, will never be “complete enough” for some critics.

    From there the conversation moves into gray-market peptides, why Mike separates his own risk tolerance from what he'd recommend to the public, and why there currently isn't a single peptide he'd recommend for muscle growth despite the demand. The back half covers his real thesis: that appearance, not health, is the most reliable motivator most people actually respond to and that chasing it tends to produce the same outcomes doctors have failed for decades to sell through fear.

    Key Takeaways

    Mike takes tirzepatide (Zepbound/Mounjaro) year-round at 5mg/week and adds retatrutide during cutting phases, both well within studied dose ranges

    He argues most GLP-1 “anhedonia” is caloric-deficit anhedonia, not a direct drug effect, the same thing bodybuilders experience on any aggressive diet

    New aggregate mortality data shows older adults on GLP-1s die less than those who aren't, which he says partially answers the “but will it kill you later” question

    There is currently no peptide he'd recommend for muscle growth, a claim he says consistently disappoints people who ask

    His core argument: use appearance as the entry point (build muscle, lose fat, sleep better) and let the longevity benefits follow, rather than trying to motivate people with 30-years-out health outcomes

    Timestamps

    00:00 Intro

    00:10 Is GLP-1 a Bad Idea?

    08:55 The Seatbelt Analogy for Drugs

    10:30 The Peptide That's Not FDA-Approved Yet

    11:30 Exactly What Mike Takes Every Week

    13:59 Stacking Peptides: an N-of-1 Experiment

    15:11 Why Mike Takes Anabolic Steroids

    16:42 The Drug That Could Replace Steroids

    18:48 Why Mike Takes Tirzepatide and Retatrutide

    21:45 20-Year Life Extension

    25:34 Mike's Full Daily Stack

    30:47 The Looksmaxxing Trojan Horse

    35:35 Sick Care vs. Health Care

    38:14 Three Exercises You Can Do Today

    40:36 Critiquing Brian Johnson's Protocol

    43:31 Is There a One-Size-Fits-All Workout?

    46:06 Zone 2 vs. Zone 5 Training

    52:21 Why Most Biohacking Is a Waste of Money

    54:01 Is HIIT Still the Rage?

    57:09 Escaping Poverty, Fueling Success

    01:04:53 Why People Take Extreme Measures to Look Good

    01:08:24 Moving Past GLP-1

    01:14:52 Everyone Will Look 22 by 2037

    01:18:24 Would You Date a 90-Year-Old?

    01:24:52 Beauty Standards in a Post-GLP-1 World

    01:25:37 The Cybernetic Revolution

    01:28:25 Living Forever in a Robot Body

    01:36:29 Will AI Cause Human Extinction?

    01:43:28 The Biggest Myth About Weight Loss

    01:44:02 Rapid Fire Questions with Mike

    01:48:06 Mike's Best Piece of Advice

    Connect with Mike:

    Website: rpstrength.com/

    Facebook: facebook.com/michael.israetel

    Instagram: @drmikeisraetel

    X: @misraetel

    Connect with Julian

    Instagram: @thebeyondtomorrowpodcast / @juliankissa

    LinkedIn: julian-issa

    X: @juliankissa

    Website: www.beyondtomorrowpodcast.com

    Email: bookings@beyondtomorrowpodcast.com

    1 hr 52 min
  11. AI Safety Expert Roman Yampolskiy WARNS About the TWO Likely Endings with AI

    Show notes

    What happens when the technology we build becomes smarter than the people who built it?

    This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at http://agelessrx.com/beyond-tomorrow

    AI safety researcher Roman Yampolskiy argues the real danger isn't AI, it's building a superintelligence we can no longer control. His case: solve problems with narrow, powerful tools instead, and still get breakthroughs in medicine, science, and productivity, without that risk.

    The conversation covers AGI, recursive self-improvement, the singularity, and the existential and "suffering" risks they raise, plus what mass automation could mean for work and purpose.

    From international AI agreements to human longevity, one question runs through it all: can we get the benefits of advanced AI without losing control of it? Yampolskiy's answer: keep building tools, not our replacement.

    Roman Yampolskiy is an AI safety researcher and professor who studies the risks and implications of artificial intelligence. His work focuses on the challenge of controlling increasingly capable AI systems and the potential consequences of superintelligence.

    Roman’s book, AI: Unexplainable, Unpredictable, Uncontrollable, explores the various reasons why the field is so challenging.

    ⏱ Timestamps

    00:00 Intro

    00:43 Can We Build AI By Design to Avoid Catastrophe?

    01:49 AI Superintelligence Is a Death Sentence

    03:12 What Is AGI, Really?

    04:26 OpenAI's Plan to Build an Internal AGI

    04:59 Why Superintelligence Won't Care About Us

    06:45 We're Going to Die Anyway... So What?

    07:06 We Can't Control Something This Advanced

    07:55 The Narrow Tools That Avoid AGI

    09:34 The US vs China AI Race

    10:47 Does China Actually Want to Stop AGI?

    11:53 AGI Is a Spectrum, Not a Switch

    12:22 Is Roman Selling the Doom Narrative?

    14:13 How to Stop AGI From Escaping the Box

    16:26 Building AI We Can't Control

    18:05 Suffering Risks: The Worst-Case Scenario

    20:09 The Two Types of Jobs

    22:09 What Happens to the 90% Who Lose Their Jobs?

    23:46 Nothing Makes AI Labs Stop

    24:26 Building Something You Can't Control

    26:06 Do You Believe in God?

    29:28 Longevity Escape Velocity Without AGI

    30:55 Is Suffering Necessary for the Human Story?

    31:33 Are We Living in a Simulation?

    32:12 You Can't Control Superintelligence

    33:24 Is Our Life a Simulation?

    35:05 Curing Aging With Narrow AI Tools

    36:10 What Is an NPC?

    36:37 Could Humans Cause Doom Before AI Does?

    37:21 How to Break Out of a Simulation

    39:14 Would You Live Forever in a Simulation?

    40:01 Don't Build Superintelligence

    41:50 Bostrom's Singleton Theory

    43:17 "AI Is Massively Overhyped"

    44:56 Would AI Doom Be Worse Than World War 3?

    45:41 Who Should You Actually Be Listening To?

    47:43 What Would a Perfect Simulation Look Like?

    50:52 Solving Longevity Without AI

    52:03 Our Limited Understanding of Human Biology

    52:40 What Makes Roman Happy?

    53:48 Signs Governments Are Waking Up

    55:14 "Is AI Just a Con?"

    56:53 Can Squirrels Control Humans?

    58:27 Decide What to Do With Your Time

    59:22 What About Ilya Sutskever?

    01:00:13 The Responsible Use of Technology

    01:00:46 If Tomorrow is Your Last Day...

    Connect with Roman:

    Website: https://www.romanyampolskiy.com/

    Facebook: https://www.facebook.com/roman.yampolskiy/

    LinkedIn: https://www.linkedin.com/in/romanyam/

    X: https://x.com/romanyam

    Connect with Julian

    Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/

    Instagram: https://www.instagram.com/juliankissa/

    LinkedIn: https://uk.linkedin.com/in/julian-issa

    Website: http://www.beyondtomorrowpodcast.com

    Email: bookings@beyondtomorrowpodcast.com

    Get exciting updates from The Beyond Tomorrow Podcast here: https://dlogos.xyz/podcasts/the-beyond-tomorrow-podcast-with-julian-issa-7bf16e9d

    1 hr 3 min
  12. BT Clip: Longevity Experts: The Tipping Point That Will Trigger a Global “War on Aging” (Matt Kaeberlein, Aubrey de Grey, and Gordan Lauc)

    Show notes

    Let's get into the rapidly evolving future of longevity, from the moment society finally believes aging is solvable to the possibility of humans routinely living far beyond today’s lifespan — even approaching 150 years. Matt Kaeberlein, Aubrey de Grey, and Gordan Lauc explore how breakthroughs in aging science could also extend the lives of companion animals, while exposing how bad science and misallocated resources continue to slow meaningful progress. It’s a grounded, forward-looking discussion on what true longevity innovation requires.

    Watch the full episode here: https://open.spotify.com/episode/1Rmtl7sqoFOWolXWV6O22U?si=cd176f6a28404b4d

    8 min
  13. DAVID EAGLEMAN: The END of Human Presidents is COMING. Should We Worry?

    Show notes

    Could an AI actually run the country better than a person could?

    This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at http://agelessrx.com/beyond-tomorrow

    David Eagleman doesn't shy away from the question. He lays out the case for an AI president, one that could crunch more data than any human cabinet, sidestep the ego and grudges that shape so many political decisions, and maybe even out-think our worst instincts.

    Sounds great, until you ask the harder questions. Who writes the code that decides what "the greater good" means? Can a machine actually be moral, or just really good at faking it? And if an AI ever did hold real power, who's holding the leash?

    We get into all of it: democracy, tribalism, consciousness, and how close we actually are to AGI. David doesn't pretend to have it all figured out but he makes a compelling case that the ground is shifting faster than most of us realize.

    David Eagleman is a neuroscientist at Stanford University and an internationally bestselling author. He is co-founder of several neurotech companies, including Jojo, BrainCheck, and Neosensory, and he also directs the Center for Science and Law, a national non-profit institute. He is best known for his work on sensory substitution, time perception, brain plasticity, synesthesia, and neurolaw.

    ⏱ Timestamps

    00:00 Intro

    00:05 Are We in the Middle of AGI?

    03:26 AI’s Greatest Advantage

    04:25 The Case for a Utilitarian AI President

    07:16 Who Defines AI’s Parameters?

    09:06 The Danger of Politically Biased AI

    11:49 Behind the Scenes

    12:33 Are We Ready for an AI President?

    14:41 What Should an AI Government Optimize For?

    18:31 How Soon Could We Have an AI President?

    22:24 The Trolley Problem and AI Morality

    27:54 What Happens When Humans Have Too Much Free Time?

    29:07 The Neuroscience of Tribalism

    30:13 The Neural Basis of Empathy

    31:24 Why We’re Wired for Us vs. Them

    32:43 Can AI Become Conscious?

    33:51 Could AI Eradicate Humanity?

    35:51 Artificial Wisdom and AI Guardrails

    38:57 AGI Is Already Happening

    41:22 An AI President in Our Lifetime

    43:26 The Biggest Fear About AI

    Connect with David:

    Website: https://eagleman.com/

    Facebook: https://www.facebook.com/David.M.Eagleman

    LinkedIn: https://www.linkedin.com/in/davideagleman/

    Instagram: https://www.instagram.com/davideagleman

    X: https://x.com/davideagleman

    TikTok: https://www.tiktok.com/@drdavideagleman

    Connect with Julian

    Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/

    Instagram: https://www.instagram.com/juliankissa/

    LinkedIn: https://uk.linkedin.com/in/julian-issa

    Website: http://www.beyondtomorrowpodcast.com

    Email: bookings@beyondtomorrowpodcast.com

    Subscribe on Spotify, Apple, and YouTube for more stories from the edge of what is possible.

    46 min
  14. BT Clip: Harvard Geneticist: "Immortality May Have Already Happened!" (George Church)

    Show notes

    What if immortality didn’t arrive as a single breakthrough but quietly, step by step?In this clip, George Church explains the idea of “longevity escape velocity”: the point where medical progress extends life faster than we age. If each generation of therapies buys us more time to develop the next, the path to dramatically longer lives or even practical immortality may already have begun.Watch the full episode here: https://open.spotify.com/episode/0c2x5fNYLSzvvfIil3c7WK?si=854bb724225e4136

    7 min
  15. Peter Diamandis: "AGI Is Already Here - They Just Haven't Released It Yet"

    Show notes

    What if the Singularity isn’t coming but already here?

    This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at http://agelessrx.com/beyond-tomorrow

    AI is accelerating breakthroughs across science, medicine, and technology at a pace once considered impossible. Peter Diamandis believes the next 5–10 years could redefine what humanity can achieve.

    Yet AI’s promise is competing with fear, disruption, and dystopian narratives. The challenge is not only building the future, but shaping how people imagine it.

    For Peter Diamandis, the answer is actionable optimism: identify the risks, believe they can be solved, and pursue the biggest moonshots. Longevity, education, and space could become the foundations of a radically different future.

    Peter Diamandis is an entrepreneur, physician, and founder of XPRIZE and Singularity University. He is a leading advocate for moonshot thinking and breakthrough technologies.

    ⏱ Timestamps

    00:00 Intro

    00:10 The Blinding Speed of Change

    02:06 A Future Where Anything Is Possible

    04:06 Why Is the West Afraid of AI?

    08:39 Why Fear AI?

    10:23 AGI Is Already Here

    11:37 Blind Optimism vs. Actionable Optimism

    13:01 The Next Great Moonshot

    14:01 The Rise of an Alien-Looking Economy

    15:10 Who Will Win the XPRIZE?

    15:46 If Tomorrow Was Your Last Day...

    Connect with Peter:

    Website: https://www.diamandis.com/

    Facebook: https://www.facebook.com/PeterDiamandis/

    LinkedIn: https://www.linkedin.com/in/peterdiamandis/

    Instagram: https://www.instagram.com/peterdiamandis

    X: https://x.com/peterdiamandis

    YouTube: https://www.youtube.com/@peterdiamandis

    Connect with Julian

    Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/

    Instagram: https://www.instagram.com/juliankissa/

    LinkedIn: https://uk.linkedin.com/in/julian-issa

    Website: http://www.beyondtomorrowpodcast.com

    Email: bookings@beyondtomorrowpodcast.com

    Subscribe on Spotify, Apple, and YouTube for more stories from the edge of what is possible.

    14 min
  16. BT Clip: AGI Pioneers: ChatGPT Won’t Get Us to AGI.. Here’s What Will (Ben Goertzel)

    Show notes

    Are large language models like ChatGPT and Claude enough to create AGI?In this clip, Ben Goertzel explains why today’s LLMs are incredibly powerful, but still fundamentally different from true artificial general intelligence.He argues that simply building a bigger version of ChatGPT or Claude is unlikely to produce human-level AGI. Instead, reaching AGI will require new AI architectures that can go beyond their training, generalize to unfamiliar problems and make genuinely novel leaps in reasoning.Ben also explains why current models can already outperform humans in areas like coding, mathematics and knowledge retrieval, while still struggling with the kind of imagination and general intelligence humans use to push beyond existing knowledge.

    Full episode here: https://open.spotify.com/episode/7wGN1x0vQQgdzoktHipqBK?si=454702357d55415e

    9 min
  17. Ben Goertzel: Whoever Gets AGI First Can CONQUER THE PLANET

    Show notes

    How close are we to AGI?

    This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at http://agelessrx.com/beyond-tomorrow

    The race toward AGI is entering a new phase. Ben Goertzel explores alternative paths to intelligence beyond simply building bigger models.

    The conversation also examines the global AI race. The U.S. and China are competing for technological leadership. But the future of AI may not remain centralized.

    Then comes the bigger question: what happens after superintelligence? Goertzel imagines AI that could protect humanity. It could even help overcome aging, disease, and other human limitations.

    Ben Goertzel is an AI researcher, futurist, and CEO of SingularityNET and BGI Labs. Widely recognized as one of the pioneers of Artificial General Intelligence, he has spent more than two decades developing decentralized AI systems designed to benefit humanity.

    What You’ll Learn

    •

    Why the AI revolution may be bigger than previous technological shifts

    •

    How AI could become an extension of human intelligence

    •

    Why agency may matter more than machine consciousness

    •

    How the brain creates a simulated model of reality

    •

    Whether consciousness could emerge on different substrates

    •

    Why AI alignment is also a problem of human alignment

    •

    How AI could help humanity become smarter and more coherent

    ⏱ Timestamps

    00:00 Intro

    00:07 What Happens in the Next 12 Months?

    03:41 Why China Is Catching Up

    07:36 Why China Wants AI Control

    10:18 Can Governments Control AI?

    13:02 Human-Level AGI vs Superintelligence

    15:35 Will ASI be Chinese or American?

    17:47 The Next Breakthrough to AGI

    21:05 How AI Could Become More Intelligent

    22:23 Why Language Powers AI

    27:33 Can Decentralized AI Change Everything?

    32:23 The Global Race vs Decentralized AI

    36:22 Would Superintelligence Protect Humanity?

    40:19 Can We Build Compassionate AGI?

    46:27 Why AI Arms Races Are Dangerous

    51:14 Why Governments Shouldn’t Control AI

    53:17 Can the Government Keep Up With AI?

    54:00 Will Open AI Challenge Big Tech?

    55:12 The Future of Decentralized AI

    56:27 Could 2045 Arrive by 2028?

    Connect with Ben

    Website: https://singularitynet.io/

    LinkedIn: https://www.linkedin.com/in/bengoertzel

    X: https://x.com/bengoertzel

    Connect with Julian

    Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/

    Instagram: https://www.instagram.com/juliankissa/

    LinkedIn: https://uk.linkedin.com/in/julian-issa

    Website: http://www.beyondtomorrowpodcast.com

    Email: bookings@beyondtomorrowpodcast.com

    Subscribe on Spotify, Apple, and YouTube for more stories from the edge of what is possible.

    52 min
  18. BT Clip: MIT Professor: "We Have 18 Months Before AI Lockdown" (Ramesh Raskar)

    Show notes

    Ramesh Raskar explains how artificial intelligence is evolving and why the coming phase may be critical for its long-term impact on society. He discusses the role of economic systems in guiding responsible innovation and the importance of moving from simply using AI tools to actively participating in their development and governance.

    Watch the full episode here: https://open.spotify.com/episode/5zyaecyejQCgbCQ2t2uTt5?si=faf738a4f4ea4a9d

    9 min
  19. These 20 Companies are Competing for $101M (XPRIZE)

    Show notes

    What if we could add 20 healthy years to human life?

    This episode is brought to you by AgelessRx, where aging becomes a puzzle that can be solved. The mission is to help you live longer and healthier by adding more life to your years through science-backed solutions and personalized care. Learn more at https://agelessrx.com/.

    That’s the ambitious challenge behind the XPRIZE Healthspan competition, where 20 finalist teams are racing to find breakthroughs that could fundamentally change how we age. Driven by the moonshot vision championed by Peter Diamandis, the goal isn’t simply to live longer, it’s to preserve muscle, cognitive, and immune function as we get older.

    In this episode, Jamie Justice takes us on a journey to better understand the XPRIZE competition as we take a closer look at Minicircle (Walter Patterson), Longeveron (Brian Rash), NYC Vita (Miriam Merad), Mitochondrial All Stars (David Brown), AgelessRx (Stefanie Morgan and Anar Isman), Ani.Ai (Bruno Balen), and Goqii (Vishal Gondal), exploring their very different approaches to extending healthy lifespan. From gene therapies and mitochondrial interventions to stem cells, AI-powered discoveries, and personalized health solutions, these teams are pushing longevity science into fascinating and largely uncharted territory.

    Dr. Jamie Justice is a geroscience researcher and Executive Vice President of Health at XPRIZE, where she leads the organization’s efforts to accelerate breakthroughs in healthy aging.

    ⏱ Timestamps

    00:00 Intro

    00:10 What Is the XPRIZE Competition?

    04:09 Why XPRIZE Isn’t a Traditional Funding Program

    05:37 The XPRIZE’s Approach to Innovation

    08:27 Peter Diamandis on the XPRIZE Winner

    08:54 Why the Moonshot Has to Be Daring

    10:31 What Makes a Breakthrough Solution?

    12:44 The Different XPRIZE Categories

    13:54 Can More Teams Still Join?

    15:24 Clinical Trials Must Finish by 2029

    18:24 The Rise of AI Based Interventions

    19:11 Unexpected Approaches to Healthspan

    22:07 Minicircle: The Non Viral Plasmid DNA Vector

    Minicircle

    24:53 Why Minicircle’s Gene Therapy Approach Is Different

    25:42 A Simpler Gene Therapy Platform

    26:29 Why Plasmid Gene Therapy May Be Safer

    28:57 The Challenges of Gene Therapy

    30:39 Pushback Against Gene Therapy

    33:04 The Future of Gene Therapy

    34:18 How Teams Are Adapting

    36:17 What It Takes to Reach the 20 Year Goal

    37:17 No More New Teams in 2028

    38:27 Why Some European Teams Are Struggling

    40:56 Could Teams Merge to Move Forward?

    42:07 Inside the Biologic Category

    Longeveron

    42:39 The Next Generation of Biologic Therapies

    46:50 What Makes This Team Unique?

    47:48 Engineering New Biologic Therapies

    53:56 Building a Super Team for Healthspan

    Featured Team: Mitochondrial All Stars

    57:28 The Role of Mitochondria in Aging

    59:27 Specializing in Mitochondrial Health

    01:00:48 The Power of a Multi Modal Team

    NYC Vita

    01:03:11 Combining Different Approaches to Aging

    01:06:37 Sharing Data Across Teams

    01:08:50 Why Collaboration Could Change the Game

    01:13:33 A Novel Drug Target for Aging

    AgelessRX

    01:14:59 A Strategic Approach to Intervention

    01:15:52 Can We Achieve 20 Years of Rejuvenation?

    01:17:18 The Chemical Combination

    01:22:12 The Science Behind the Approach

    01:22:46 The Potential of NAD+

    01:23:58 Why Japanese Teams Stand Out

    01:26:18 The $100 Million Incentive

    01:28:10 Inside the Drug Category

    01:31:57 Can We Add Healthy Life in One Year?

    Ani.Ai

    01:32:49 Healthy Life in Just One Year

    01:33:22 The Antibiome Approach

    01:36:52 What the Future of Healthspan Could Look Like

    01:38:37 The Best Piece of Advice

    Connect with Jamie

    Website: https://www.xprize.org/

    Instagram: https://www.instagram.com/j.n.justice/

    LinkedIn: https://www.linkedin.com/in/jamie-justice-ph-d-6b933146

    X: https://x.com/j_n_justice

    The Teams:

    Minicircle: https://minicircle.io/

    Longeveron: https://longeveron.com/

    NYC Vita: https://www.mountsinai.org/

    AgelessRX: https://agelessrx.com/

    Ani.Ai: https://www.ani.ai/

    Goqii: https://goqii.com/us-en

    1 hr 46 min
  20. BT Clip: AI Will END Democracy Before We Even Notice… (Emad Mostaque)

    Show notes

    Is democracy already becoming obsolete in the age of AI?

    Emad Mostaque, founder of Intelligent Internet, shares why he believes the status quo is over, why democracy as we know it cannot survive the rise of superintelligent AI, and why the race for AGI could determine who controls the future of humanity.

    In this clip, Emad explains why AI may eventually replace human decision-making, how power is becoming concentrated in the hands of a few AI companies, and why governments must rethink ownership, governance, and the role of AI before it's too late.

    Watch the full episode here: https://open.spotify.com/episode/6oqWQWDYX90uQUmZ5hcB4Q?si=2ada02e898e44ea6

    12 min

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