Podcast

Decera Clinical Education Oncology Podcast

Courses, Education, Health & Fitness, Medicine

Updates on new data and best practices in the care of patients with cancer across a wide variety of solid tumors and hematologic malignancies from Decera Clinical Education. Gain practical clinical insights and strategies and earn CME/CE credit for selected episodes.

Episodes
274
Releases
Twice a week
Typical length
27 min
On air since
2020
Latest episode
5 days ago

Episodes

274 episodes, newest first

  1. TROP2-Directed ADCs in NSCLC: Current Evidence, Emerging Therapies, and Future Treatment Strategies

    Episode 278

    Show notes

    In this podcast episode, Christine M. Bestvina, MD, and Joshua E. Reuss, MD, discuss the current and emerging role of TROP2-directed ADCs in NSCLC, including:

    • Current clinical use of Dato-DXd in previously treated EGFR-mutated NSCLC, including evidence from TROPION-Lung01 and TROPION-Lung05 and considerations for treatment sequencing
    • Emerging efficacy data for investigational TROP2 ADCs, including sacituzumab tirumotecan, and the potential role of these agents in earlier lines of therapy
    • Ongoing clinical trials evaluating TROP2 ADCs alone and in combination with immunotherapy, chemotherapy, or EGFR-targeted therapies, including TROPION-Lung07, TROPION-Lung08, TROPION-Lung14, TROPION-Lung15, and AVANZAR
    • Biomarker-guided patient selection, including the potential of the TROP2 QCS-NMR biomarker to identify patients most likely to benefit from Dato-DXd
    • Safety and supportive care considerations, including prevention and management of stomatitis, ocular toxicities, and interstitial lung disease/pneumonitis

    Get access to all of our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify.

    Presenters:

    Christine M. Bestvina, MD
    Associate Professor of Medicine
    Section of Hematology/Oncology
    Division of Medicine
    University of Chicago Medicine
    Chicago, Illinois

    Joshua E. Reuss, MD
    Thoracic Medical Oncologist
    Director of Thoracic Clinical Research
    Associate Professor of Medicine
    Georgetown Lombardi Comprehensive Cancer Center
    Washington, DC

    Link to full program:
    https://bit.ly/4iumiap

    Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

    30 min
  2. Experts Discuss Key Topics in Treatment for Newly Diagnosed Multiple Myeloma

    Episode 276

    Show notes

    In this podcast episode, Jesus G. Berdeja, MD, and Ajai Chari, MD, discuss evolving therapy in newly diagnosed multiple myeloma, including:

    • Selecting quadruplet therapy
    • Optimal use of bortezomib
    • The role of autologous stem cell transplantation in the quadruplet era
    • Use of MRD status to inform treatment decisions
    • Maintenance strategies

    Presenters:

    Jesus G. Berdeja, MD
    Director of Myeloma Research
    Greco-Hainsworth Centers for Research
    Partner
    Tennessee Oncology
    Nashville, Tennessee

    Ajai Chari, MD
    Professor of Clinical Medicine
    Director of Multiple Myeloma Program
    UCSF Helen Diller Family Comprehensive Cancer Center
    University of California, San Francisco (UCSF) Medical Center
    San Francisco, California

    Content based on an online CME program supported by an educational grant from GSK.

    Link to full program:https://bit.ly/4yTeLZD
    https://bit.ly/4yTeLZD

    Get access to all of our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify.

    Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

    24 min
  3. PARP Inhibitors in Metastatic Prostate Cancer: Biomarker Testing, Treatment Strategies, and Toxicity Management

    Episode 275

    Show notes

    In this podcast episode, Neeraj Agarwal, MD, FASCO, and Emmanuel S. Antonarakis, MD, discuss the evolving role of PARP inhibitors in metastatic prostate cancer, emphasizing early molecular testing to identify appropriate patients for PARP-directed therapy and proactive adverse event management to support treatment continuation, including:

    • HRR alterations and the mechanism of action of PARP inhibitors
    • Germline and somatic genomic testing and practical considerations for tissue and ctDNA testing
    • PARP inhibitor monotherapy and combination strategies, including data from AMPLITUDE and TALAPRO-3
    • Treatment selection across metastatic prostate cancer settings based on HRR alterations
    • PARP inhibitor toxicity management, with emphasis on anemia, gastrointestinal effects, monitoring, and dose modification

    Presenters:

    Neeraj Agarwal, MD, FASCO
    Medical Oncologist, Dana-Farber Cancer Institute
    Co-Director, Prostate Cancer Program, Harvard Cancer Consortium
    The Lank Center for Genitourinary Oncology
    Boston, Massachusetts

    Emmanuel S. Antonarakis, MD
    Clark Endowed Professor of Medicine
    Director of GU Oncology, Associate Director of Translation
    Division of Hematology, Oncology and Transplantation
    University of Minnesota, Masonic Cancer Center
    Minneapolis, Minnesota

    Link to full program:
    https://bit.ly/4dtT35U

    Get access to all of our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify.

    Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

    27 min
  4. Experts Discuss Sequencing of Therapies for Relapsed/Refractory Multiple Myeloma

    Episode 274

    Show notes

    Listen to Jesus G. Berdeja, MD, and Ajai Chari, MD, as they discuss sequencing of antibody–drug conjugates (ADCs), bispecific antibodies, CAR T-cell therapy, and other novel treatment modalities for patients with relapsed/refractory multiple myeloma.

    Presenters:
    Jesus G. Berdeja, MD
    Director of Myeloma Research
    Greco-Hainsworth Centers for Research
    Partner
    Tennessee Oncology
    Nashville, Tennessee

    Ajai Chari, MD
    Professor of Clinical Medicine
    Director of Multiple Myeloma Program
    UCSF Helen Diller Family Comprehensive Cancer Center
    University of California, San Francisco (UCSF) Medical Center
    San Francisco, California

    Content based on an online CME program supported by an educational grant from GSK.

    Link to full program:
    https://bit.ly/3TZSmuf

    Get access to all of our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify.

    Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

    29 min
  5. ASCO 2026 Updates in Metastatic Breast Cancer

    Episode 273

    Show notes

    In this podcast episode, Hope S. Rugo, MD, FASCO, and Nerea Lopetegui-Lia, MD, discuss practice-informing data presented at ASCO 2026 for patients with metastatic breast cancer, including:

    • Findings from SERENA-6 on ctDNA-guided treatment switching for emergent ESR1 mutations before radiographic progression, including updated PFS2 and downstream treatment outcomes
    • Emerging precision strategies in HR-positive/HER2-negative advanced breast cancer from ELEVATE and PIKALO-1, including elacestrant plus capivasertib and mutant-selective PI3Kα inhibition with tersolisib
    • First-line TROP2-directed ADC data from ASCENT-04, ASCENT-03, and TROPION-Breast02, with discussion of PFS2, subsequent therapy, immunotherapy eligibility, and treatment sequencing

    Presenters:
    Hope S. Rugo, MD, FASCO
    Director, Women’s Cancer Program
    Division Chief, Breast Medical Oncology
    Professor, Department of Medical Oncology & Therapeutics Research
    City of Hope Comprehensive Cancer Center
    Professor Emeritus and Emeritus Winterhof Family Distinguished Professor of Breast Oncology
    University of California, San Francisco
    San Francisco, California

    Nerea Lopetegui-Lia, MD
    Assistant Professor
    Division of Medical Oncology, Breast Section
    Department of Internal Medicine
    The Ohio State University
    Columbus, Ohio

    Get access to all of our new podcasts by subscribing to the Decera Clinical Education [Oncology] Podcast on Apple Podcasts, YouTube Music, or Spotify.

    Link to full program:
    https://bit.ly/4x4u5AT

    Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

    19 min
  6. Evolving Role of B7-H3–Directed ADCs in the Extensive-Stage Small-Cell Lung Cancer Treatment Landscape

    Episode 272

    Show notes

    In this podcast episode, Charles Rudin, MD, PhD, and Mark A. Socinski, MD, discuss current gaps and clinical needs for patients with relapsed ES-SCLC, and the evolving role of B7-H3–directed antibody–drug conjugates in the management of patients with ES-SCLC, including:

    • Clinical needs for relapsed ES-SCLC
    • Scientific rationale for targeting B7-H3 and other tumor-associated antigens in SCLC
    • ADCs, T-cell engagers, chemotherapy-based approaches, maintenance strategies, and ongoing clinical trials for ES-SCLC
    • Recent efficacy and safety data for B7-H3–directed ADCs in ES-SCLC, including I-DXd
    • Personalization of care of patients with SCLC, including patient-specific factors influencing treatment
    • Case discussion of a patient with ES-SCLC requiring optimal next best treatment
    • Importance of enrolling patients in ongoing trials of investigational agents for patients with ES-SCLC

    Presenters:
    Charles Rudin, MD, PhD
    Cancer Center Director
    Memorial Sloan Kettering Cancer Center
    New York, New York

    Mark A. Socinski, MD
    Executive Medical Director
    AdventHealth Cancer Institute
    Orlando, Florida

    Link to full program:
    https://bit.ly/3UBEeYz

    Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

    35 min
  7. Targeting CDH6 in Platinum-Resistant Ovarian Cancer: Emerging ADCs, Biomarkers, and Sequencing

    Episode 271

    Show notes

    In this podcast episode, BJ Rimel, MD, and Elizabeth Lee, MD, discuss the scientific rationale for targeting CDH6 in ovarian cancer and the emerging role of CDH6-directed antibody–drug conjugates (ADCs) in platinum-resistant disease, including:

    • CDH6 biology, expression patterns, and its potential as a therapeutic target in ovarian cancer
    • Early-phase efficacy data with investigational CDH6-directed ADCs, including raludotatug deruxtecan (R-DXd) and CUSP06, and an ongoing phase III trial of R-DXd
    • Safety considerations with CDH6-directed ADCs, including cytopenias, gastrointestinal toxicities, fatigue, and interstitial lung disease/pneumonitis
    • Considerations for sequencing ADCs, including the potential impact of target expression, payload class, and mechanisms of resistance

    Presenters:

    BJ Rimel, MD
    Division Chief, Gynecologic Oncology
    Professor, Department of OB/GYN
    University of Washington
    Clinical Director of Gynecologic Oncology
    Fred Hutchinson Cancer Center
    Seattle, Washington

    Elizabeth Lee, MD
    Division of Gynecologic Oncology
    Center for Cancer Therapeutic Innovation
    Department of Medical Oncology
    Dana-Farber Cancer Institute
    Boston, Massachusetts

    Link to full program:
    https://bit.ly/3SqCAZ6

    Get access to all of our new podcasts by subscribing to the Decera Clinical Education Podcast on Apple Podcasts, YouTube Music, or Spotify.

    Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

    29 min
  8. ASCO 2026 Updates in Early Hormone Receptor–Positive Breast Cancer

    Episode 270

    Show notes

    In this podcast episode, Hope S. Rugo, MD, FASCO, and Nerea Lopetegui-Lia, MD, discuss practice-informing data presented at ASCO 2026 for patients with early-stage hormone receptor (HR)–positive/HER2-negative breast cancer, including:

    • Findings from the OPTIMA trial evaluating Prosigna gene expression testing to guide adjuvant chemotherapy decisions in patients with high-risk HR-positive/HER2-negative early breast cancer
    • The importance of ovarian function suppression plus endocrine therapy when considering chemotherapy-sparing strategies in premenopausal patients
    • Results from the NATALEE PAM50 biomarker analysis, showing ribociclib benefit across intrinsic subtypes with no significant treatment-by-subtype interaction

    Presenters:

    Hope S. Rugo, MD, FASCO
    Director, Women’s Cancer Program
    Division Chief, Breast Medical Oncology
    Professor, Department of Medical Oncology & Therapeutics Research
    City of Hope Comprehensive Cancer Center
    Professor Emeritus and Emeritus Winterhof Family Distinguished Professor of Breast Oncology
    University of California, San Francisco
    San Francisco, California

    Nerea Lopetegui-Lia, MD
    Assistant Professor
    Division of Medical Oncology, Breast Section
    Department of Internal Medicine
    The Ohio State University
    Columbus, Ohio

    Get access to all of our new podcasts by subscribing to the Decera Clinical Education [Oncology] Podcast on Apple Podcasts, YouTube Music, or Spotify.

    Link to full program:
    https://bit.ly/4x4u5AT

    Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

    9 min
  9. CELMoDs on the Horizon: A New Chapter in Lymphoma Care

    Episode 269

    Show notes

    Treatment options for patients with lymphoma are rapidly evolving. In this podcast episode, Alex F. Herrera, MD, and Marc Hoffmann, MD, discuss cereblon E3 ligase modulators (CELMoDs) as potential treatment options for patients with aggressive diffuse large B-cell lymphoma and follicular lymphoma, with a focus on golcadomide, an investigational, oral, first-in-class CELMoD therapy. Topic areas covered include:

    • Biologic and clinical rationale for the use of CELMoD therapy in lymphoma patients
    • Emerging clinical trial data on golcadomide alone and in combination with other regimens
    • Real-world expectations for incorporating CELMoD-based therapies into community lymphoma care settings such as efficacy, patient selection, and toxicity management strategies

    Presenters:

    Alex F. Herrera, MD
    Chief, Division of Lymphoma
    Professor, Department of Hematology and Hematopoietic Cell Transplantation
    Director, Toni Stephenson Lymphoma Center
    City of Hope
    Duarte, California

    Marc Hoffmann, MD
    Director, Lymphoma Program
    Medical Director, Lean and Quality Improvement
    Associate Professor
    Division of Hematologic Malignancies and Cellular Therapeutics
    University of Kansas Cancer Center
    Kansas City, Kansas

    Content based on an online CME program supported by an educational grant from Bristol Myers Squibb.

    Get access to all of our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify.

    Link to CME: Claim Credit

    Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

    23 min
  10. Experts Discuss Health Disparities and Equitable Care Strategies in Multiple Myeloma

    Episode 267

    Show notes

    In this podcast episode, Jesus G. Berdeja, MD, and Ajai Chari, MD, discuss health disparities and equitable care strategies in multiple myeloma, including:

    • Treatment for underserved populations
    • Navigating REMS for novel therapeutics
    • Clinical trial design and enrolment

    Presenters:
    Jesus G. Berdeja, MD
    Director of Myeloma Research
    Greco-Hainsworth Centers for Research
    Partner
    Tennessee Oncology
    Nashville, Tennessee

    Ajai Chari, MD
    Professor of Clinical Medicine
    Director of Multiple Myeloma Program
    UCSF Helen Diller Family Comprehensive Cancer Center
    University of California, San Francisco (UCSF) Medical Center
    San Francisco, California

    Content based on an online CME program supported by an educational grant from GSK.

    Link to full program:
    https://bit.ly/3TZSmuf

    Get access to all of our new podcasts by subscribing tothe Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify.

    Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

    14 min
  11. Experts Discuss CELMoD Agents for Multiple Myeloma

    Episode 268

    Show notes

    In this podcast episode, Meletios-Athanasios (Thanos) C. Dimopoulos, MD, and María-Victoria Mateos, MD, PhD, as they discuss the use of CELMoD agents to manage multiple myeloma, including:

    • The recent FDA approval of iberdomide
    • Mechanism of action and differentiation from IMiDs
    • Current data and potential treatment settings

    Presenters:
    Meletios-Athanasios (Thanos) C. Dimopoulos, MD
    Professor and Chairman
    Plasma Cell Dyscrasias Unit
    Section of Hematology and Medical Oncology
    Department of Clinical Therapeutics
    School of Medicine
    National and Kapodistrian University of Athens
    Alexandra Hospital
    Athens, Greece

    María-Victoria Mateos, MD, PhD
    Myeloma Unit, Director
    Professor of Medicine
    University Hospital of Salamanca
    Salamanca, Spain

    Content based on an online CME program supported by an educational grant from Bristol Myers Squibb.

    Link to full program:
    https://bit.ly/4xgnHri

    Get access to all of our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify.

    Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

    26 min
  12. Optimizing Oral Targeted Therapies for HR+/HER2- Breast Cancer

    Episode 265

    Show notes

    In this episode, Danielle Roman, PharmD, BCOP, and Jordan Hill, PharmD, BCOP, discuss optimal care for patients with HR-positive/HER2-negative breast cancer receiving newer oral targeted therapies. Their conversation addresses treatment selection across early-stage and metastatic disease, biomarker-informed decision-making, adverse event management, and practical strategies to help patients remain on therapy.

    Key topics include:

    • Selecting and sequencing oral targeted therapies, including CDK4/6 inhibitors, PARP inhibitors, PI3K/AKT pathway inhibitors, and oral SERDs
    • Identifying patients with high-risk early breast cancer and applying evidence from trials such as monarchE, NATALEE, and OlympiA
    • Using biomarkers such as BRCA1/2, PIK3CA, AKT1, PTEN, and ESR1 to guide therapy in metastatic disease
    • Monitoring and managing treatment-related adverse events, including neutropenia, diarrhea, hepatotoxicity, QTc prolongation, hyperglycemia, rash, stomatitis, anemia, nausea, and fatigue
    • Using dose modification, supportive care, patient education, and proactive follow-up to improve adherence and persistence with oral therapy
    • Incorporating oncology pharmacists and the multidisciplinary care team into ongoing treatment monitoring and patient support

    Presenters
    Danielle Roman, PharmD, BCOP
    Manager, Oncology Clinical Pharmacy Services
    Oncology Clinical Pharmacy Specialist
    Allegheny Health Network
    Pittsburgh, Pennsylvania

    Jordan Hill, PharmD, BCOP
    Clinical Pharmacy Specialist, Breast Oncology
    West Virginia University Cancer Institute
    Morgantown, West Virginia

    Get access to all of our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify. Access the full educational program:

    Link to full program:
    https://bit.ly/4gvZerW

    And be sure to try our Interactive Decision Support Tools for Early Breast Cancer and Selecting AKT or PI3K Inhibitors for Patients With Metastatic Breast Cancer. By answering just a few quick questions, you can see what 5 experts would recommend for specific patient scenarios.

    Early Breast Cancer:
    https://bit.ly/4gtUiUq

    AKT or PI3K Inhibitors in MBC:
    https://bit.ly/4qcyBvk

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    33 min
  13. TGCT Today: Understanding Diagnosis, Treatment, and Long-term Care

    Episode 266

    Show notes

    Tenosynovial giant cell tumor (TGCT) is a rare, locally aggressive disease that can cause chronic pain, joint dysfunction, reduced mobility, and significant impacts on quality of life, particularly in patients with diffuse disease. In this expert discussion, Dr William Tap and Dr Emanuela Palmerini explore the evolving management of TGCT, including the biologic role of the CSF1/CSF1R pathway, challenges in diagnosis and disease monitoring, and the importance of multidisciplinary, patient-centered care. They also discuss the growing role of CSF1R-targeted therapies, treatment selection, toxicity management, drug holidays, and practical approaches to optimizing long-term outcomes for patients living with TGCT.

    Topics Covered

    • Understanding localized vs diffuse TGCT
    • Biology of the CSF1/CSF1R pathway
    • Diagnostic approaches and the role of MRI and biopsy
    • Multidisciplinary care and shared decision-making
    • Impact of TGCT on function, mobility, and quality of life
    • Current and emerging CSF1R-targeted therapies
    • Pexidartinib and vimseltinib: clinical considerations and toxicity management
    • Response assessment beyond imaging
    • Drug holidays, retreatment strategies, and long-term follow-up
    • Future directions in TGCT research and treatment

    Faculty

    • William Tap, MD
    • Emanuela Palmerini, MD, PhD

    Get access to all of our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify.

    Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

    36 min
  14. Optimizing Anti-CD38–Based Treatment for Smoldering and Newly Diagnosed Multiple Myeloma: Pharmacist Perspectives

    Episode 264

    Show notes

    In this podcast episode, James A. Davis, PharmD, BCOP, and Kelley L. Julian, PharmD, BCOP, discuss evidence-based strategies for managing smoldering and newly diagnosed multiple myeloma, including:

    • Risk stratification and treatment selection for smoldering multiple myeloma
    • Anti-CD38–based regimens for transplant-eligible and transplant-ineligible patients
    • Clinical evidence supporting triplet and quadruplet therapies
    • MRD assessment and response-adapted treatment strategies
    • Frailty, transplant eligibility, and individualized treatment selection
    • Subcutaneous anti-CD38 administration and premedication requirements
    • Pharmacist-led supportive care, toxicity management, dose modification, and patient counseling

    Get access to all of our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify.

    Presenters:
    James A. Davis, PharmD, BCOP
    Clinical Pharmacy Specialist, Myeloma/Lymphoma
    The Medical University of South Carolina, Hollings Cancer Center
    Affiliate Assistant Professor
    MUSC College of Pharmacy
    Charleston, South Carolina

    Kelley L. Julian, PharmD, BCOP
    Hematology/BMT Pharmacy Supervisor
    PGY2 Oncology Pharmacy Residency Program Director
    Huntsman Cancer Institute, University of Utah
    Salt Lake City, Utah

    Link to full program:
    https://bit.ly/4qaRb7n

    Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

    29 min
  15. New and Emerging Targeted Therapies for Patients With DLBCL

    Episode 263

    Show notes

    In this podcast episode, Gilles Salles, MD, PhD, and Pier Luigi Zinzani, MD, PhD, discuss the role of new and emerging targeted therapies in the management of patients with DLBCL, including:

    • Overview of Unmet Needs With Current Standard of Care in DLBCL
    • Expanding Role of Novel Agents in DLBCL
    • Access to Targeted Therapies and Clinical Trials in Non-Academic DLBCL Practice
    • Key Ongoing Trials of new and novel agents in DLBCL
    • Key Presentations/Results at EHA 2026 in DLBCL

    Presenters:

    Gilles Salles, MD, PhD
    Service Chief, Lymphoma Service
    Steven Greenberg Chair
    Memorial Sloan Kettering Cancer Center
    Weill Cornell University
    New York, New York

    Pier Luigi Zinzani, MD, PhD
    Professor of Hematology
    Alma Mater Studiorum-University of Bologna
    Head, “Seràgnoli” Institute of Hematology
    IRCCS Azienda Ospedaliero-Universitaria di Bologna
    Department of Medical and Surgical Sciences
    Bologna University School of Medicine
    Bologna, Italy

    Link to full program:
    https://bit.ly/4gmyoS7

    Get access to all of our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify.

    Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

    39 min
  16. Changing the Paradigm in HER2-Positive Early Breast Cancer

    Episode 262

    Show notes

    New data and broad indications for trastuzumab deruxtecan are changing the paradigm for HER2-positive early breast cancer. Listen to Shanu Modi, MD, and Sara A. Hurvitz, MD, FACP, discuss how they are incorporating these changes into clinical practice in the neoadjuvant, adjuvant, and possibly metastatic settings.

    Presenters:

    Sara A. Hurvitz, MD, FACP
    Professor of Medicine
    Smith Family Endowed Chair in Women’s Health
    Senior Vice President, Clinical Research Division
    Fred Hutch Cancer Center
    Head, Division of Hematology/Oncology, Department of Medicine
    University of Washington School of Medicine
    Seattle, Washington

    Shanu Modi, MD
    Section Head, HER2 Breast Program
    Professor and Attending Member
    Breast Medicine Service, Department of Medicine
    Memorial Sloan Kettering Cancer Center
    Weill Cornell Medical College
    New York, New York

    Link to full program:
    https://bit.ly/4z1Xb6a

    Get access to all of our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify.

    Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

    25 min
  17. Recent Advances, Future Directions, and Ideas on Integrating CELMoDs Into The Care Of Patients With Myeloma

    Episode 255

    Show notes

    Listen in to learn from Sagar Lonial, MD, and Mohamad Mohty MD, PhD, about the advantages and future implications of the next-generation protein degradation modulator based therapy and find out how to integrate their use into your practice.

    Presenters:
    Sagar Lonial, MD, FACP, FASCO
    Chair and Professor
    Department of Hematology and Medical Oncology
    Anne and Bernard Gray Family Chair in Cancer
    Chief Medical Officer
    Winship Cancer Institute
    Emory University School of Medicine
    Atlanta, Georgia

    Mohamad Mohty, MD, PhD
    Sorbonne University
    Paris, France

    Get access to all of our new podcasts by subscribing to the Decera Clinical Education Oncology Podcast on Apple Podcasts, YouTube Music, or Spotify.

    Visit the program page for more content associated with this discussion.

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    18 min
  18. To Treat or Not to Treat: Assessing Risk and Treatment Options in High-Risk SMM

    Episode 261

    Show notes

    In this podcast episode, Natalie S. Callander, MD, and Tom Martin, MD, discuss the optimal approaches for the determination of whether a patient with high-risk SMM requires treatment or observation, including:

    • Contemporary Risk Stratification
    • Interpreting Evidence for Early Intervention
    • Treatment vs Observation: Patient Selection
    • Treatment Selection and Sequencing Considerations
    • Safety, Monitoring, and Supportive Care
    • Implementation in Practice
    • Shared Decision-making and Patient Communication
    • Emerging Therapies and Clinical Trials

    Presenters:

    Natalie S. Callander, MD
    Professor of Medicine
    Director, Myeloma Clinical and
    Cellular Therapy Program
    University of Wisconsin Carbone
    Cancer Center
    Madison, Wisconsin

    Tom Martin, MD
    Professor of Medicine
    Associate Chief, Hematology/Oncology
    UCSF Medical Center
    San Francisco, California

    Link to full program:
    https://bit.ly/4wqpYzU

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    48 min
  19. Unmet Needs, Recent Advances, and Expert Insights on Integrating TROP-2 ADCs Into the Care of Patients With TNBC

    Episode 260

    Show notes

    Listen in to learn from Thomas Bachelot, MD, PhD, and Mafalda Oliveira, MD, PhD, about recent advances and the integration of anti-TROP2 antibody-drug conjugates (ADCs) into the management of patients with triple-negative breast cancer, including as first-line therapy for those who are not eligible for immunotherapy. Experts will cover:

    • The evolving role of TROP2-directed antibody-drug conjugates (ADCs), including sacituzumab govitecan and datopotamab deruxtecan, in addressing unmet needs in the frontline treatment of TNBC.
    • Treatment sequencing, reimbursement barriers to recent approvals, and toxicity-informed treatment selection considerations.
    • How to monitor and manage ocular and pulmonary toxicities and care-team readiness for implementing ADC-based therapy in routine practice.

    Presenters:
    Thomas Bachelot, MD, PhD
    Medical Oncology
    Department of Oncology
    Léon Bérard Center
    Lyon, France

    Mafalda Oliveira, MD, PhD
    Senior Consultant
    Medical Oncology Department
    Vall d’Hebron University Hospital
    Senior Clinical Investigator
    Breast Cancer Group
    Vall d’Hebron Institute of Oncology (VHIO)
    Vall d’Hebron Barcelona Hospital Campus
    Barcelona, Spain

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    22 min
  20. Optimizing Bispecific Antibody Safety and Care Coordination From the Pharmacy in RRMM

    Episode 259

    Show notes

    In this episode, Dr Sara Ann Scott and Dr Syeda Saba Kareem discuss toxicities and the safe management of bispecific antibodies used in the treatment of RRMM to improve outcomes for patients, including:

    • The incidence of cytokine release syndrome (CRS), along with the grading system, treatment strategies, and the role of tocilizumab
    • Neurologic toxicities like the clinical manifestation of ICANS and the ICE scoring system used to help assign grading and appropriate treatment with dexamethasone, levetiracetam, and/or high-dose methylprednisolone
    • Infection susceptibilities associated with BCMA-targeted bispecific antibodies and how this varies for GPRC5D-directed targets throughout therapy
    • How to set up and maintain a REMS program

    Get access to all of our new podcasts by subscribing to the Decera Clinical Education Podcast on Apple Podcasts, YouTube Music, or Spotify.

    Presenters:

    Syeda Saba Kareem, PharmD, BCOP
    Clinical Pharmacy Supervisor
    Malignant Hematology
    Moffitt Cancer Center
    Tampa, Florida

    Sara A. Scott, PharmD, BCOP
    Clinical Pharmacy Specialist,
    Multiple Myeloma
    Emory Winship Cancer Institute
    Atlanta, Georgia

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    https://bit.ly/3RUyrMx

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    31 min