Nick Norwitz MD PhD - Metabolic Health & Longevity

In this conversation with Mike Mutzel, MS from the High Intensity Health channel, we dive into some of the most interesting 2025 heart health studies. We explored the gut-heart axis, how body fat can alter blood vessel function and touch on oxidative stress, inflammation, the microbiome, protein, hormones and how they all relate to heart health. If you are interested in cardiovascular health nutrition, and metabolism, this one is for you!

Chapter
*Call our service line at 815-STAY-CUR (815-782-9287) or visit https://askchapter.org/staycurious

*Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2

Mike’s YouTube Channel: https://www.youtube.com/user/highintensityhealth

For Deeper Dive’s into the Content Discussed:

*Referenced Videos:

Paper 1: Imidazole Propionate and Heart Health https://youtu.be/P7CZvAnB53E

Autophagy and Depression https://youtu.be/MCCb5VkckU0

Paper 2: Aging, Phenylacetic Acid and Heart Health https://youtu.be/H0OaXcIobgM

Young Blood and Longevity https://youtu.be/lTMjmHKc2Ys

Paper 3: Myeloperoxidase, Obesity and Heart Health https://youtu.be/inTK-9DCxf0

*Other Referenced Content:

Homovanillic Acid, Microbiome and Depression https://staycuriousmetabolism.substack.com/p/the-microbiomemood-link-a-three-ingredient?r=40ekz2

Dogs and health https://staycuriousmetabolism.substack.com/p/the-science-of-dogs-and-better-health?r=40ekz2

Leptin, Salt and Blood Pressure https://staycuriousmetabolism.substack.com/p/salt-vs-fat-rethinking-the-root-causes?r=40ekz2

Four Types of Diabetes (The Cliffhanger!): https://staycuriousmetabolism.substack.com/p/types-four-of-diabetes-what-new-technologies?r=40ekz2

Chapters:

00:00 – Dipping into 2025 Heart Health Studies
2:25 – The Shift in Heart Health Focus Beyond ApoB and LDL
8:03 – Imidazole Propionate and Heart Health – And Internet Confusion
22:15 – Chapter: Healthcare and Longevity
24:02 – Gut Health, Heart Health, Aging and Phenylacetic Acid
26:50 – Mechanisms to Improve Gut Metabolism and Lower Phenylacetic Acid
37:45 – How Fat Tissue and Myeloperoxidase Impact Vascular Health
43:23 – Final Reflections: A Systems View of Metabolic Health

*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options.

#metabolichealth #mikemutzel #nicknorwitz #2025healthstudies #inflammation #phenylaceticacid #apob #hearthealth #lipidstudies #guthealth #sleepandmetabolism #insulinresistance #myeloperoxidase #autophagy #longevityscience #nutritionalbiochemistry #healthoptimization #functionalmedicine #healthscience #chronicinflammation #cardiovascularrisk #biomarkers #longevityresearch #metabolicmarkers #functionalmedicine #healthscience #chronicinflammation #cardiovascularrisk #biomarkers #longevityresearch #metabolicmarkers #staycurious

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For more nuances and references, see the associated Newsletter: https://staycuriousmetabolism.substack.com/p/can-we-trap-a-microbial-toxin-to?r=40ekz2

Winnow Microplastic Binding Probiotic, Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUS

Microplastics and Cardiovascular Disease, Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2

A new study has uncovered a surprising metabolic villain — D-lactate, the molecular twin of the lactate that fuels your muscles. Unlike L-lactate, D-lactate builds up in people with obesity and contributes to insulin resistance, fatty liver, and metabolic dysfunction. But scientists have now found a way to trap this molecule in the gut, potentially opening the door to a brand-new class of metabolic therapies. In this video, Nick Norwitz MD PhD explains the study, its implications for human health, and how certain probiotics and homemade yogurts could help reduce D-lactate levels naturally.

Chapters:
0:00 – The Evil Twin of Lactate: New Research Explained
1:18 – L-Lactate vs D-Lactate: Why the Difference Matters
2:43 – Elevated D-Lactate in Obesity: The Hidden Connection
3:18 – How D-Lactate Worsens Blood Sugar and Metabolic Health
4:00 – Gut Microbes: The Source of D-Lactate
6:30 – The D-Lactate Trap: How Scientists Made Mice Poop It Out
9:11 – What This Discovery Means for Metabolic Research
9:42 – Practical Takeaways: What You Can Do Right Now

#Lactate # microbiome #metabolichealth #fatloss #insulinsensitivity #diabetes #obesity #weightloss #educationa #staycurious #inflammation #yogurt #guthealth #biochemistry #metabolism #glucosecontrol #bloodsugar #fattyliver #insulinresistance #healthscience #nutritionresearch #probiotics #gutmicrobiome #scienceexplained #wellnessscience #hormones #metabolicsyndrome

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Link: https://pubmed.ncbi.nlm.nih.gov/29317623/

Newer Video (April 2024): https://youtu.be/pr93EsEV2bM?si=AEcnv1jlUoEWF-e1

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For references and a written breakdown, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/weve-been-prescribing-statins-wrong?r=40ekz2

For a consolidated resource on prior StayCurious Heart Health Content, check out our Heart Health Map! https://open.substack.com/pub/staycuriousmetabolism/p/the-intricate-metabolic-web-of-heart?r=40ekz2&showWelcomeOnShare=true

Statins are among the most prescribed and profitable drugs in the world, but new research is forcing us to rethink what they actually do — and for whom. In this video, Dr. Nick Norwitz MD PhD breaks down the latest data showing that statins only reduce cardiovascular risk in people with existing heart disease, while showing little or no benefit for those without.

Nick walks through, not one, but 4 major studies and explains why LDL cholesterol and ApoB aren’t the whole story, how coronary imaging (CAC or CTA scans) provide better risk prediction, and why the real root causes — like insulin resistance and mitochondrial dysfunction — often get ignored. This isn’t about conspiracy or fear — it’s about context. Good medicine isn’t black or white — it’s nuanced, transparent, and collaborative.

Chapters
0:00 – Intro: Statins as a Misunderstood Tool
1:46 – Paper 1, Statins Don’t Benefit Those Without Heart Disease
3:43 – Imaging Beats LDL and ApoB for Risk Stratification
4:26 – Paper 2, If Your Heart is Clear, Does LDL Cholesterol Matter?
5:33 – Reviewing the Pros and Cons of Statins
6:43 – Paper 3, Statins Harm Mitochondria and Muscles
7:55 – Paper 4, Statins Slash GLP-1 Levels
9:00 – The Essential Social Dynamics of Statins You Need to Know
11:15 – Conclusion, The Right Tool for the Right Job

#Statins #HeartHealth #Cholesterol #LDL #ApoB #InsulinResistance #MetabolicHealth #Mitochondria #Type2Diabetes #CardiovascularHealth #Medicine #Pharmaceuticals #GLP1 #CoQ10 #StayCurious #NickNorwitz #Educational #ScienceCommunication #CriticalThinking #HealthResearch #StayCurious

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Shawn Baker Tweet: https://x.com/SBakerMD/status/1728878646793003085?s=20

Nick Tweet: https://x.com/nicknorwitz/status/1729122883564171274?s=20

0:12: Data “leak”

0:50: Who am I? (For those who don’t know me)

1:54: Lean Mass Hyper-Responders

2:56: What (design and hypothesis)

5:15: Why am I doing this?

7:13 – 9:40: “How” (Lipid Energy Model)

Other details and Final comments

Lipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/
LMHR, first paper: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext
JCL LMHR editorial: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltext
LMHR, low saturated fat case report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/

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Microplastics and Cardiovascular Disease Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2

Winnow Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUS
Winnow is a first-in-class probiotic that binds microplastics to provide a microplastic shield from your inside. See the letter above for more details.

Inulin StayCurious Newsletter: https://staycuriousmetabolism.substack.com/p/the-fiber-that-fights-fat-how-inulin?r=40ekz2

Inulin Video: https://youtu.be/blNLHsww_Qs

Andrew Koutnik, Interview 1: https://youtu.be/2doAS18X9kA
Andrew Koutnik, Interview 2: https://youtu.be/-vdol1TSxoc
Andrew Koutnik, Interview 3: https://youtu.be/NrZlvtWIgBA

In this episode, Dr Andrew Koutnik and I dive deep into the science of fiber, keto, and more – focusing on two influential 2025 papers. First, we unpack the a new study revealing how a specific type of fiber can “immunize” the body against fructose by reshaping the microbiome, protecting the liver, reducing de novo lipogenesis, and boosting glutathione production. This isn’t “more fiber is better”—it’s precision nutrition.

Then we break down the keto mouse study that was widely discuss for claiming ketogenic diets cause fatty liver and glucose intolerance. We explain why this particular mouse model leads to misleading results, and how diet design specifics dramatically change outcomes. When viewed through these lenses, the scare headlines collapse.

We also explore how to think critically about nutrition science, why animal studies can both illuminate and mislead, how individuals can apply evidence with nuance, and why personal experimentation—combined with skepticism and curiosity—leads to better metabolic outcomes. If you're trying to understand fiber, fructose, ketogenic diets, diabetes, or simply want to make better decisions about your own metabolic health, this conversation provides clarity and actionable insight.

Chapters:
0:00 – Intro: Welcome Back Dr Andrew Koutnik PhD
1:40 – The Coolest Fiber Paper Ever!
21:19 – Probiotic That Binds Plastics
22:52 – Keto Mouse Myths: A Shady Study Skews the Truth
30:01 – Andrew Reflects on his Diary of a CEO Appearance
43:01 – Do Credentials Teach Curiosity, or Crush Them?

#NickNorwitz #AndrewKoutnik #MetabolicHealth #NutritionScience #Inulin #FiberScience #Microbiome #GutHealth #Fructose #HFCS #LiverHealth #NAFLD #Metabolism #InsulinResistance #KetogenicDiet #KetoScience #LowCarb #Type1Diabetes #PrecisionNutrition #LongevityScience #Healthspan #ScientificDebunk #DietStudies #EvidenceBasedNutrition #ScienceExplainer #StayCurious #Glutathione #Mitochondria #DeNovoLipogenesis #MicrobiomeResearch

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JRE #2069, Spotify: https://open.spotify.com/episode/6BVcDMKLN820nNXYSPcbwv

Oreo experiment, Video: https://youtu.be/GHALacs44I8?si=Oec-0YqamBj5dO1X
Oreo experiment, Tweet: https://x.com/nicknorwitz/status/1729122883564171274?s=20

Carnivore, Harvard Study: https://pubmed.ncbi.nlm.nih.gov/34934897/
LMHR study: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext
Lipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/

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For references, extra nuances and my Lp(a) protocol, see this letter: https://staycuriousmetabolism.substack.com/p/why-lpa-may-not-be-as-dangerous-as?r=40ekz2

Relevant Prior Videos
Lp(a) Background Video: https://youtu.be/iVwDJqJiTEY
Lp(a) and Vitamin C Video: https://youtu.be/3rbJnKnhg3s
MPO Video: https://youtu.be/inTK-9DCxf0

Lipoprotein(a), or Lp(a), is one of the most feared genetic risk factors for heart disease. But new 2025 data tell a far more hopeful story.

In this video, I break down a large, long-term study showing that Lp(a)-related cardiovascular risk depends heavily on metabolic context, especially waist-to-hip ratio — a simple marker of visceral fat. Shockingly, in people with low waist-to-hip ratios, even high Lp(a) levels were not associated with increased heart disease risk.

We walk through the data, the graphs, the mechanisms (clotting, inflammation, oxidative stress), and the practical takeaways.

Genes are not destiny. Metabolic health changes the story.

Chapters
0:00 – I Have Lp(a)… Oh No!
1:47 – New Study on Waist-to-Hip Ratio and Lp(a)
2:47 – High Lp(a) But Low WHR… Low Risk!
3:31 – Look At This Graph!
4:28 – And Now Look at These Graphs!
5:45 – Your Waist-to-Hip Ratio Goals
7:23 – Mechanisms: Why Would Waist-to-Hip Ratio Matter for Lp(a) Risk?
10:11 – Teasing the Protocol… See More at StayCurious Metabolism
11:00 – Summarizing Key Points

#LpA #HeartHealth #CardiovascularDisease #Genetics #MetabolicHealth #VisceralFat
#WaistToHipRatio #Atherosclerosis #Inflammation #OxidativeStress #PrecisionHealth
#Longevity #HealthScience #PreventiveCardiology #NickNorwitz #StayCurious

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Peter and Derek: https://www.youtube.com/watch?v=sl0LrPYZoTY

Lipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/
LMHR, first paper: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext
JCL LMHR editorial: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltext
LMHR, low saturated fat case report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/

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For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/can-visceral-fat-cause-depression?r=40ekz2

Chapter
*Call our service line at 815-STAY-CUR (815-782-9287)
*Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2

Visceral Fat Randomized Controlled Trial Video: https://youtu.be/lDeegZ1wtAI

Description:
Most people think of fat as extra weight—something cosmetic or something to “burn off.” But new science is showing something far more profound: visceral fat is an endocrine organ that sends biochemical messages across the entire body, including directly into the brain. And those messages can change mood, increase stress sensitivity, and even promote depression.

In this video, we break down a brand-new study revealing how visceral fat releases tiny molecular packages called extracellular vesicles. Inside those vesicles is a specific microRNA—a signal that can cross the blood-brain barrier, impair neurons in the hippocampus, lower BDNF, and induce depression-like behavior in animal models.

This emerging research provides a mechanistic explanation for why obesity and depression are so tightly linked, why mood disorders often worsen with metabolic disease, and why improving metabolic health may improve mental health.

Finally, we explore what you can do today—how reducing visceral fat may lower miR-145-5p, improve brain resilience, and break the vicious metabolic–mood loop. Your metabolism and your mind are not separate systems. They are one.

Chapters:
0:00 – Visceral Fat: More Than Storage
1:03 – Can Fat Cause Depression? New Biology
2:26 – The Obesity–Depression Loop
3:32 – Mechanism: How Visceral Fat Sends Signals to the Brain
5:07 – miR-145-5p: The Molecular “Letter” Driving Depression
9:19 – What You Can Do: Reducing Visceral Fat to Protect Brain Health

#visceralfat #depression #metabolichealth #extracellularvesicles #microRNA #brainhealth #inflammation #mentalhealth #obesityresearch #healthscience #NickNorwitz #StayCuriousMetabolism

*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options.

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Link: https://jn.nutrition.org/article/S0022-3166(23)72806-X/fulltext
https://authors.elsevier.com/sd/article/S0022-3166(23)72806-X

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Dom D’Agostino Part 1 Interview: https://youtu.be/ksV9f4jSbLQ

Creatine Letter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2

Sardine Diet Letter: https://staycuriousmetabolism.substack.com/p/sardine-fasting-the-ultimate-health?r=40ekz2
Sardine Diet Video: https://youtu.be/_Th54GWd8WY

Lived to 117 Letter: https://staycuriousmetabolism.substack.com/p/the-oldest-woman-117-had-high-cholesterol?r=40ekz2
Lived to 117 Video: https://youtu.be/U7UY8ZPKNlM

Stress Makes Sugar Letter: https://staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2
Stress Makes Sugar Video: https://youtu.be/7ekVEYlKFfE

This interview with Professor Dom D’Agostino is one of the most information-dense conversations I’ve had on the channel. We dive into the real science behind melatonin — why it doesn’t suppress your hormones and why its neuroprotective effects might matter more than its sleep benefits.

We explore creatine far beyond muscle performance, including its impact on brain energy and cognitive resilience, and how to take it without the GI issues many people experience.

We also break down the surprising biology of a verified 117-year-old woman, what her data reveals about longevity, and why factors like mindset, mitochondria, and microbiome may matter more than any single biomarker.

And finally, we tackle sardine fasting — why it may be the most elite, nutrient-dense, muscle-sparing fasting protocol available. If you want cutting-edge science translated into practical strategies for metabolic health, brain health, and longevity, this is the episode to watch.

Chapters
0:00 – Welcome Back Professor D’Agostino
1:34 – Does Melatonin Suppress Your Hormones?
6:27 – Real Benefits of Melatonin
8:00 – Creatine for Brain Health
10:24 – How to Reduce GI Upset from Creatine
14:04 – How Did This Woman Live to 117?
30:00 – Sardine Fasting: The Most Elite Form of Fasting

#melatonin #creatine #sardines #sardinediet #fasting #longevity #brainhealth #metabolichealth #neuroprotection #omega3 #NickNorwitz #DomDAgostino #StayCurious #nutritionresearch #healthscience #biohacking #antiaging #ketodiet #ketosis #healthoptimization #supplements #exercisephysiology #functionalnutrition #lowcarb #cholesterol #labresults #epigenetics #mitochondria #inflammation #mentalclarity #superfoods #metabolismboost #wellnessjourney #lifespan #healthylonglife

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Link to paper: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/full

Adrian Soto Mota MD PhD Tweet: https://x.com/AdrianSotoMota/status/1737733204734579062?s=20

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For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/the-true-story-of-the-cookie-that?r=40ekz2

Oreo vs Statin Paper: https://pubmed.ncbi.nlm.nih.gov/38276308/
Lipid Energy Model Paper: https://pubmed.ncbi.nlm.nih.gov/35629964/

What if Oreo cookies could lower cholesterol faster — and more powerfully — than a multi-billion-dollar statin drug? That’s the question I set out to test in a 5-month controlled self-experiment I ran as a Harvard Medical School student. And the results were so shocking they were eventually published in peer-reviewed literature.

This video shares the full story — why my LDL cholesterol skyrocketed into the 500s after going ketogenic, the physiology behind the lean-mass hyper-responder phenomenon, and how adding 12 Oreo cookies per day dropped my LDL twice as much as high-dose statin therapy and in one-third of the time.

But this isn’t just about cookies…This is a video about challenging assumptions, testing mechanisms, provoking curiosity, and using a viral headline to shine light on a deeply misunderstood physiological phenomenon.

Chapters
0:00 – I Used Oreo Cookies to Lower My LDL
1:06 – Why My Cholesterol Skyrocketed in the First Place
4:43 – The True Mechanism Behind the LDL Rocket ship
7:53 – Why Oreos vs Statin Worked So Well
11:00 – What Does this Oreo Cookie Cholesterol Drop Really Mean?
12:33 – What is the Risk of High Cholesterol in People Like Me?
14:08 – What We Now Know

#cholesterol #LDL #hearthealth #metabolism #LMHR #lipidenergymodel #LEM #exercise #ApoB #cardiovasculardisease #obesity #staycurious #VLDL #triglycerides #metabolichealth #educational #metabolichealth #cholesterol #LDL #statins #ketodiet #lipidenergymodel #leanmasshyperresponder #metabolichealth #healthscience #ApoB #nutritionresearch #NickNorwitz #StayCurious #cardiovascularhealth #scienceeducation #cholesterolmyth

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Prior Response video: https://youtu.be/ILuEO7Jc8TY?si=RCPFWtRDC09Pst5s

LMHR CCTA study drop: https://youtu.be/IMkDwtJVeB0?si=yx-zbFnfkLNtZeuL

OreovsStatin leak video: https://youtu.be/GHALacs44I8?si=9IOAgZTl3sMnVg6L

Peter Libby Review: https://www.nature.com/articles/s41586-021-03392-8

Norwitz et al 2021: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext

Cooper et al 2023: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/full

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For references and a written breakdown, see the associated Stay Curious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/new-hope-for-alzheimers-can-apoe2?r=40ekz2

Lithium for Brain Health: https://staycuriousmetabolism.substack.com/p/lithium-and-alzheimers-the-harvard?r=40ekz2

Ketone Cleans the Brain, Video: https://youtu.be/oRaNzfHF_do

Chapter
*Call our service line at 815-STAY-CUR (815-782-9287)
*Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2

I carry two copies of APOE4 — the gene variant that increases Alzheimer’s risk 10–15-fold. For years, that terrified me. But emerging research provides hope. The study we will review suggests that adding APOE2 might quiet brain inflammation, reduce plaques, and help save neurons. In today’s video, I break down the research in simple terms and what this could mean for the future of Alzheimer’s therapy. Then I’ll share the evidence-based strategies that I personally use to protect my brain while we wait for next-generation gene therapies: lithium orotate, ketosis, omega-3s, and more.

Chapters
0:00 – Why I’m Determined to Prevent Alzheimer’s
1:28 – An Incredible Picture of Neuroinflammation
2:06 – APOE2, APOE3, APOE4: What These Genes Really Mean
3:54 – The Big Question: Is There an Antidote to APOE4?
5:36 – APOE2 Therapy: Reduced Plaques and Silenced Neuroinflammation
7:19 – Chapter: The Right Insurance Saves Money and Life-Years
8:33 – My 3 Neuroprotection Essentials: Lithium, Ketosis and Omega-3s

#alzheimersdisease #apoe4 #brainhealth #longevity #dementia #neuroscience #educational #staycurious #Alzheimers #BrainHealth #Neuroinflammation #CognitiveHealth #DementiaPrevention #APOE2 #Genetics #Longevity #Neuroscience #Metabolism #Ketosis #LithiumOrotate #Omega3 #HealthyBrainAging #StayCurious #Neuroprotection #Microglia #Amyloid #BrainOptimization

*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options.

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What I liked: I like the concept of 'bringing the viewer along with the science.' I agree with the fact that the SAD eating pattern is problematic and that it would be an improvement to eat a whole food-based diet. I also (very much) acknowledge there are non-health related issues about food that we should have adult discussions about.

What I didn't like:
(1) This series wasn't really about the twin study. Data were only presented, a bit, in the last of the 4 episodes.
(2) The advertised foods (fake meat, fake cheese, fake eggs) are cast as similar/identical, but simply aren't, nor were they the basis of the participant's diets.
(3) The data presented were, I think, not all that impressive. And some data presented in the documentary could not be found in the paper, e.g. body composition.

For more on the topic of Data Misrepresentation, see our new paper: https://www.sciencedirect.com/science/article/pii/S002231662372806X?via%3Dihub

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For a mini-masterclass in blood sugar control, see: https://staycuriousmetabolism.substack.com/p/7-ways-to-lower-blood-sugar-without?r=40ekz2
For the Stress Creates Sugar Letter: https://staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2
Statin Slash GLP-1 Video: https://youtu.be/6NomrgjK1yQ

In this interview, Dr. Nick Norwitz MD PhD sits down once again with Dr. Andrew Koutnik PhD to unpack several groundbreaking research papers, including how psychological stress can cause your liver to make sugar from scratch, how different carbs and fibers impact bodies differently depending on metabolic health, how potatoes can tell you if you’re insulin sensitive, and more. If you’ve ever wondered how stress, nutrition, and biology collide to shape your health, this conversation might change the way you think about your body—and your mind.

Chapters:
00:00 — The new stress-sugar discovery
01:10 — How your brain signals your liver to make glucose
04:30 — The real mechanism behind “stress-induced sugar spikes”
07:00 — Andrew’s story: TED Talk stress sent glucose up 100 mg/dL
10:20 — How sprinting saved him from a glucose crash
12:00 — What this means for diabetics and the general population
14:30 — Why meditation changes your biology (not just mindset)
16:00 — How obesity amplifies stress’s metabolic effects
17:00 — The ‘semi-myth’ of fiber protection in insulin resistance
21:30 — Personalized nutrition and CGM insights
24:00 — Potatoes vs Grapes test for insulin resistance
27:00 — GLP-1 dysfunction, statins, and “new species of diabetes”
38:00 — The future of metabolic precision medicine

#Cortisol #Glucose #BrainHealth #LiverHealth #Type1Diabetes #Type2Diabetes #Hormones #NutritionScience #Mitochondria #HealthOptimization #Neuroscience #Endocrinology #MetabolicFlexibility #LowCarb #KetogenicDiet #FunctionalMedicine #ChronicStress #Biohacking #HealthResearch #ScienceCommunication #Educational #Informative #StayCurious

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Link: https://pubmed.ncbi.nlm.nih.gov/38237807/

0:00: intro
0:15: NEW paper!
0:38: Low-Carb for various diseases
0:57: LDL boogeyman
1:17: Lean Mass Hyper-Responder #LMHR
1:35: The BIG question
2:11: Intro to NEW study, meta-analysis of RCTs
2:46: BMI Results!
4:43: Not the Saturated Fat!
5:58: Lipid Energy Model
6:56: Conclusion

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For more nuances and references, see the associated Newsletter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2

Winnow Microplastic Binding Probiotic, Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUS

Most people think of plastic as an environmental problem—something that harms oceans, wildlife, and ecosystems. But emerging science is revealing something far more personal: microplastics don’t just pollute the planet— they may be poisoning your heart.

A landmark study published in the New England Journal of Medicine found microplastics and nanoplastics embedded inside human arterial plaque. Even more alarming, patients with these particles inside their arteries had a 350% higher risk of heart attack, stroke, or death.

This research suggests microplastics may drive cardiovascular disease through oxidative stress, inflammation, immune activation, and vascular damage. Under the microscope, jagged plastic fragments were found lodged inside macrophages—immune cells that normally clear debris—triggering inflammation and accelerating plaque instability.

We also explore what you can do today—from reducing heat-exposed plastics, filtering water, and improving air quality, to emerging research on internal defense strategies aimed at binding microplastics before they’re absorbed. This isn’t fear. It’s empowerment. Knowledge isn’t meant to panic us—it’s meant to protect us. Stay curious.

Chapters
0:00 – Plastic Poisons the Heart. But There’s Good News!
1:15 – Find More Information at StayCurious Metabolism
1:41 – A Landmark NEJM Study
2:42 – 350% Increased Risk of Heart Attack, Stroke and Death!
4:15 – Microplastics Associate with Inflammation
5:02 – Microplastics Lodged in Macrophage Immune Cells
6:41 – Comparison to LDL Cholesterol
8:15 – How to Reduce Your Exposure to Microplastics
9:54 – A Probiotic That Shields You from Microplastics

#microplastics #cardiovasculardisease #microbiome #hearthealth #heartdisease #NEJM #microplastics #hearthealth #cardiovasculardisease #nanoplastics #inflammation #science #longevity #metabolichealth #heartattack #stroke #healthscience #NickNorwitz #StayCuriousMetabolism

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