The Male Room with Dr. Jesse Mills

Dr. Rena Malik is back with Dr. Mills to discuss her new book, The Hard Truth: Everything Men Need to Know for Good Health, Great Sex, and Long Life. From eating your way to better erections to understanding why your pelvic floor might need more stretching than strengthening, Dr. Malik shares practical tips for improving your sexual health without overhauling your entire life. Plus, why the company you keep can affect your sex life, how to navigate mismatched libidos, and why couples should stop obsessing over how often they’re having sex. It’s a candid, funny, and reassuring conversation about building a better sex life at any age.

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Dr. Rena Malik is one of the most followed urologists in the world, with millions turning to her for frank, science-backed advice about sexual health. This week, she joins Dr. Mills to discuss how she built her online following, why so many men suffer in silence, and how to separate legitimate medical advice from the misinformation flooding social media. From unproven supplements and experimental peptides to the dangers of taking viral health claims at face value, Dr. Malik shares her tips for figuring out who — and what — to trust. Plus, she opens up about the interviews that changed her perspective, the future of AI in medicine, and what matters most to her beyond the exam room.

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What does it really take to change your life after a cancer diagnosis? In part two of their conversation, Dr. Jesse Mills and urologist Dr. Susan MacDonald explore how cancer transformed her approach to nutrition, inspiring her to embrace a plant-based diet, give up alcohol, and discover the surprising benefits of growing her own food. She shares practical advice for building healthier habits, making sustainable lifestyle changes, and overcoming the inevitable setbacks along the way. Plus, Dr. MacDonald opens up about the powerful practices of gratitude and self-awareness that have helped her navigate her diagnosis and find renewed purpose in life.

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What if changing the way you eat could change the way you live? Dr. Jesse Mills welcomes back urologist Dr. Susan MacDonald, who shares how her diagnosis of stage four breast cancer transformed her relationship with food, health and the things that matter most. Drawing on her experiences as both a physician and an avid gardener, she offers practical tips for eating healthier, from simple meal-prep hacks to incorporating more fiber, fruits and vegetables into your diet. She also shares her powerful personal story of facing a life-altering diagnosis, finding purpose in the face of uncertainty and discovering what it truly means to live life to the fullest.

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Dean Pohlman of Man Flow Yoga is back for Part 2, and this time we’re getting into what yoga can actually do for men’s bodies — from stiff hips and aching backs to better workouts and even better erections. Dean explains why mobility problems can sabotage your lifts, how core and hip strength can help protect your lower back, and the surprising connection between breathing, the pelvic floor and sexual function. He also busts some common fitness myths and lays out how quickly guys can expect to feel and see results from a regular mobility practice. Plus, Jordan learns there may still be hope for touching his toes.

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Think yoga isn’t for you? This week, Dr. Jesse Mills sits down with Man Flow Yoga founder Dean Pohlman to explain why flexibility and mobility matter just as much as strength — especially as men get older. Dean breaks down how yoga can help fill the gaps in traditional workouts, improve range of motion and balance, reduce stiffness, and potentially lower the risk of injuries whether you’re lifting weights, running, or playing weekend pickleball. Plus, he shares practical advice for getting started even if you can barely touch your toes, including why just 15 minutes a day can make a noticeable difference.

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In the third and final installment of our prostate-cancer trilogy with UCLA urologic oncologist Dr. Wayne Brisbane, Dr. Mills walks a 55-year-old patient through the modern treatment menu—active surveillance, focal therapy, surgery, and radiation—and why “having prostate cancer” doesn’t always mean “operate immediately.” Dr. Brisbane breaks down how doctors risk-stratify tumors (including what Gleason scores really mean), why PSA “ups and downs” can trigger anxiety, and how newer tools (from genomic tests to MRI-guided radiation) help personalize decisions. They also get real about side effects and recovery, from muscle-sparing prostatectomy techniques that can speed urinary control to the “sunburn in the bladder” sensations some men feel after radiation. The takeaway: treat the cancer the way it’s asking to be treated—and don’t be afraid to slow down, get second opinions, and choose the option that best matches your life. (Originally published March 3, 2026)

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We’ve all heard the rules: drink eight glasses of water, walk 10,000 steps, eat breakfast and maybe hold off on that diet soda. But how much of that advice is actually backed by science? This week, Dr. Jesse Mills sorts fact from fiction on some of the most common health and wellness claims, from detoxes and alkaline water to coffee and apple cider vinegar. He explains which rules are useful guidelines, which are mostly hype — and why healthy habits aren’t always one-size-fits-all.

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On Part 2 of our prostate cancer series, Dr. Mills welcomes back UCLA urologic oncologist Dr. Wayne Brisbane to walk listeners through what happens after a PSA bump — touching on how doctors use prostate MRI, biomarkers, and shared decision-making to determine who really needs a biopsy. Dr. Brisbane demystifies the MRI experience (yes, the loud, tight tube), explains what those 1–5 “PIRADS” scores actually mean, and breaks down modern biopsy options—including why the transperineal approach can lower infection risk. Then it’s on decoding Gleason scores, grade groups, and “risk stratification”— and explaining why, for many men, this is a highly treatable, often curable disease when caught early. (Originally aired February 24, 2026)

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Does stress literally break your balls? Dr. Jesse Mills is joined by urologist and men’s health specialist Dr. Susan MacDonald to break down the many causes of testicular and scrotal pain, from infections and pelvic floor dysfunction to chronic nerve pain. They explain why imaging doesn’t always reveal the source, how constipation and stress can contribute to symptoms, and why pelvic floor physical therapy may be an important part of treatment. Plus, Dr. MacDonald explains spermatic cord denervation, a surgical option that can offer relief for some men living with chronic testicular pain.

Follow Dr. MacDonald here for more information on chronic pain: @DrSusanMacDonald

More information about the Pelvic Health and Rehabilitation Center can be found here: https://www.youtube.com/@PelvicHealth

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With September being prostate awareness month, we're resharing our lengthy discussion with UCLA urologic oncologist and surgeon-scientist Dr. Wayne Brisbane. In our first installment, Dr. Mills tackles the most confusing—and most important—starting point: screening. What does an “elevated PSA” actually mean, why is it controversial, and how do you avoid unnecessary panic (or unnecessary procedures) while still catching cancer early? Using a real-world “55-year-old patient journey,” they break down PSA as a prostate “thermometer,” when to repeat a test, what role MRI plays today, and how newer tools like urine biomarkers and micro-ultrasound are reshaping early detection—before the series moves on to diagnosis and treatment. (Originally aired February 17, 2026)

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Today's episode is a ball buster — literally. Dr. Mills tackles the subject no man wants to think about: genital trauma. Using the story of a pro baseball player who finished an at-bat with a ruptured testicle as a jumping-off point, he explains what can happen when the penis or testicles suffer a serious injury, how doctors repair the damage, and why timing matters. From testicular rupture and protective cups to penile reconstruction and even transplants, Jesse walks through some of the most extreme cases urologists encounter — and the warning signs that mean it’s time to get to the ER.

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Wellness trends are everywhere—but which ones actually live up to the hype? Dr. Jesse Mills puts some of the internet’s buzziest supplements and health hacks under the microscope, breaking down the evidence behind colostrum, fibermaxxing, berberine, magnesium, probiotics and more. He explains where the science looks promising, where the claims get ahead of the data, and why even a seemingly harmless supplement may not be right for everyone. Plus, Dr. Mills and Jordan the Producer explore raw milk, fecal transplants, the gut microbiome and the complicated science behind metabolism and weight.

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Dr. Mills takes a closer look at creatine—what it does, who may benefit from it, and whether it lives up to the hype. He breaks down the evidence on muscle growth, athletic performance, kidney health, and emerging research into possible cognitive benefits. Dr. Mills also explains when creatine may be most useful, how much of a difference it can realistically make, and why you don’t need to spend extra on elaborate formulations.

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Dr. Kymora B. Scotland returns for part two of a deep dive into enlarged prostates, this time focusing on what happens when the “big boys” require more than an office-based procedure. From robotic Aquablation and GreenLight vaporization to HoLEP and simple prostatectomy, she breaks down how urologists tackle larger glands—and the tradeoffs involving bleeding, recovery, ejaculation, and incontinence. We also explore what happens when prostate obstruction becomes dangerous enough to threaten kidney function, and whether there’s anything younger men can do to reduce their odds of developing BPH down the road.

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When medications aren’t enough to tame an enlarged prostate, what comes next? In Part 1 of this two-part episode, Dr. Mills is joined by fellow UCLA urologist Dr. Kymora Scotland to break down the growing menu of procedures for BPH (benign prostatic hyperplasia), from the longtime standard TURP to minimally invasive options like UroLift, iTind, Optilume and Rezūm. They explain how prostate size, recovery time, ejaculation, fertility and potential side effects can determine which treatment makes the most sense. Plus, Dr. Scotland explains why, for most men, choosing a procedure is less about finding the single “best” option and more about finding the right one for their priorities.

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When is a strange symptom just part of getting older—and when is it a warning sign you should never ignore? Dr. Mills breaks down the red flags that warrant medical attention, including unexplained bleeding, persistent chest pain, sudden severe headaches, new lumps, shortness of breath, and a cough that won’t go away. He also explains why some frightening symptoms may be less dangerous than they appear, while seemingly minor changes can signal something serious.

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Dr. Mills breaks down the surprisingly complex process behind a seemingly simple bodily function, from the signals in your brain to the muscles of the bladder and prostate. He explains what urgency, nighttime bathroom trips, a weak stream and incomplete emptying may reveal about your health—and when they warrant a visit to the doctor. He also explores how caffeine, alcohol, medications, diabetes and heart problems can affect urinary habits, along with the risks of routinely holding it in. Plus, why does the urge suddenly strike when you reach your front door?

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Could the quality of your erections reveal more about your overall health than you realize? Dr. Mills speaks with emergency physician and FirmTech founder Dr. Elliot Justin about a wearable erection ring designed to measure nocturnal erections, sexual performance and potential early signs of cardiovascular disease. They explore why erectile difficulties are not always solved by taking a pill, how objective data could transform men’s sexual healthcare and whether FirmTech rings (and others) may help men maintain stronger, longer-lasting erections. Plus, Dr. Justin addresses privacy concerns surrounding intimate health data and previews the next generation of sexual-health wearables.

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Writer and Peyronie’s disease advocate Don Cummings joins Dr. Mills to share the deeply personal—and often surprisingly funny—story behind his memoir, Bent But Not Broken. Don recounts the fear, guilt and depression he experienced after developing Peyronie’s at age 48, as well as the long treatment journey that ultimately restored his sexual function. He also explains how support from his husband, family, friends and fellow patients helped him cope with the condition’s emotional toll. Together, they offer an honest and hopeful reminder that Peyronie’s disease does not have to mean the end of intimacy, identity or a fulfilling sex life.

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