Hump Day Hormones

We celebrate graduations, weddings, birthdays, and so many other milestones. So why does menopause often go unrecognized?

In Episode 89, we're joined by TEDx speaker and author Keri Mangis to talk about reclaiming menopause as a rite of passage and recognizing the personal growth that can come with this stage of life.

Menopause is a natural biological transition, but that doesn't mean women should have to suffer through its symptoms. This conversation explores how we can acknowledge the emotional significance of menopause while still advocating for proper medical care.

In this episode, we break down:

Why menopause deserves to be recognized as a major life transition

The emotional and physical challenges women experience during menopause

How hormonal changes and identity shifts can overlap during midlife

Keri's concept of "Pause Day" and what it means

Changing the conversation around aging and elderhood

Letting go of people pleasing and setting healthier boundaries

Embracing personal growth while still treating menopause symptoms

How we can better prepare the next generation of women

We also discuss Keri's book, The Essential Ingredient: Remaking Ourselves in Times of Crisis, which explores how challenging periods in life can become opportunities for meaningful transformation.

Find Keri's book here: https://www.amazon.com/dp/B0HB8LRBZM

Menopause doesn't have to mean losing who you are. For many women, it can be a time to reconnect with themselves, reconsider old expectations, and approach the next chapter with a new perspective.

🎧 Listen now on Spotify & Apple Podcasts!

Spotify: https://open.spotify.com/show/1iSysEIOB5evL5pcXv70J8

Apple Podcasts: https://podcasts.apple.com/us/podcast/hump-day-hormones/id1776875758

Share this episode with a woman who could use a different perspective on menopause!

Menopause Awareness | Midlife Transformation | Women's Health | Menopause And Identity | Healthy Aging | Menopause Support | Personal Growth | Keri Mangis

#HumpDayHormones #Menopause #Perimenopause #WomensHealth #MidlifeWomen #HealthyAging #MenopauseAwareness #HormoneHealth #KeriMangis

You’re exhausted, your hair is shedding, and you’re struggling with brain fog. Your blood work comes back, and you’re told you’re not anemic. But did anyone check your iron stores?

A normal hemoglobin does not necessarily mean you have enough iron. In this episode, we break down ferritin, iron deficiency without anemia, and the updated diagnostic guidance that may help identify deficiencies that were previously overlooked.

We also explore how iron connects with heavy menstrual bleeding, thyroid function, inflammation, and the hormonal changes that happen during perimenopause and menopause.

In this episode, we break down:

• The difference between hemoglobin, serum iron, and ferritin, and what each tells us
• What the updated American Society of Hematology diagnostic guidance says about ferritin thresholds
• Why iron deficiency can cause fatigue, hair shedding, brain fog, restless legs, and reduced exercise tolerance even without anemia
• How heavy or unpredictable bleeding during perimenopause can deplete iron stores
• Why persistent iron deficiency after menopause deserves further investigation
• How iron deficiency and thyroid function are connected, including why iron supplements need to be separated from levothyroxine
• What inflammation and hepcidin have to do with iron absorption and availability
• When oral or IV iron may be appropriate, why follow up matters, and why taking iron without checking your levels can be harmful

We also talk about what the evidence does and doesn’t tell us about ferritin targets, hair regrowth, hormone health, and fatigue. Low iron can be part of the picture without explaining every symptom, and a higher ferritin number is not automatically better.

The takeaway? Don’t stop at “you’re not anemic.” Your symptoms, iron stores, bleeding history, and other possible causes all deserve to be considered together.

Share this episode with someone who has been told they’re not anemic but still doesn’t feel like themselves.

Iron Deficiency | Ferritin Levels | Perimenopause Symptoms | Iron And Thyroid Function | Heavy Menstrual Bleeding | Menopause Health | Iron Deficiency Without Anemia | Women’s Health

#HumpDayHormones #IronDeficiency #Ferritin #Perimenopause #MenopauseHealth #WomensHealth #ThyroidHealth #HormoneHealth #IronDeficiencyAnemia

What happens when you have your last baby in your late 30s or early 40s and your hormones never seem to “go back to normal”?

Pregnancy, postpartum, breastfeeding, and perimenopause are often treated like completely separate stages. But for women having babies later in life, those transitions can overlap in ways that make it difficult to understand what is actually happening.

In this episode, we look at the dramatic hormonal changes that happen during pregnancy and after delivery, what breastfeeding does to estrogen and ovarian function, and why a woman who has a baby at 39 may not be returning to the same reproductive stage she was in before pregnancy.

In this episode, we break down:

• Why having a baby later in life can bring the postpartum and perimenopause transitions closer together
• Just how dramatically estrogen and progesterone rise during pregnancy and fall after delivery
• How breastfeeding can keep estrogen levels low and affect the return of ovulation
• Why ovarian aging continues during pregnancy and breastfeeding
• The symptoms that can overlap between postpartum hormone changes and perimenopause
• What may point more toward perimenopause once breastfeeding has decreased or ended
• Why perimenopause is primarily a clinical diagnosis and cannot be ruled in or out by one FSH or estradiol test
• How a history of PMS, PMDD, or postpartum depression may relate to sensitivity to reproductive hormone changes

We also clear up an important misconception: having a baby at 39 does not cause perimenopause or suddenly age the ovaries. Pregnancy may simply hide the reproductive changes that are already happening as a woman gets older.

Instead of asking, “Why haven’t my hormones recovered from having the baby?” we need to ask a bigger question: What changed, and where is this woman in her reproductive stage now?

Because sometimes, postpartum doesn’t mean you’re stuck in the postpartum stage.

Sometimes, postpartum becomes perimenopause.

Share this episode with a woman who had a baby in her late 30s or early 40s and has wondered why she still doesn’t feel like herself.

Postpartum Hormones | Perimenopause | Hormone Changes After Pregnancy | Breastfeeding And Hormones | Perimenopause Symptoms | Women’s Hormonal Health | Reproductive Aging | Women’s Health

#HumpDayHormones #Perimenopause #Postpartum #PostpartumHormones #HormoneHealth #WomensHealth #Breastfeeding #PerimenopauseSymptoms #WomensHormones

Postpartum psychosis is rare, but it is a real psychiatric emergency. And despite the increased attention around postpartum mental health, many people still don’t know what postpartum psychosis actually looks like or how different it is from postpartum depression.

In this episode, we’re joined by Dr. Shona L. Ray Griffith, a psychiatrist with UAMS Women’s Mental Health Clinic, for a conversation focused on the science behind postpartum psychosis. We talk about why it can appear in women with no previous psychiatric diagnosis, the connection with bipolar disorder, hormonal changes, sleep deprivation, genetics, and what families need to know.

In this episode, we break down:

• What postpartum psychosis actually is and how it differs from postpartum depression
• Why postpartum psychosis is so closely associated with bipolar disorder
• Why it can sometimes appear in women with no previous psychiatric diagnosis
• The potential roles of reproductive hormones, sleep deprivation, and genetics
• How newer treatments involving the allopregnanolone and GABA A pathways have changed postpartum mental health care
• Current treatment strategies and where medications like SSRIs and hormones fit
• Warning signs families and clinicians should recognize
• When symptoms become an emergency and immediate psychiatric evaluation is needed

We also talk about prevention, what can be done before and immediately after a future pregnancy for someone who has experienced postpartum psychosis, and what researchers are learning about this condition.

Postpartum psychosis is not simply postpartum depression that has become more severe. Knowing the difference can help families recognize warning signs sooner and understand when it is time to seek urgent help.

Share this episode with a partner, family member, or healthcare provider who should know more about postpartum mental health.

Postpartum Psychosis | Postpartum Mental Health | Bipolar Disorder | Women’s Mental Health | Postpartum Depression | Maternal Mental Health | Perinatal Psychiatry | Women’s Health

#HumpDayHormones #PostpartumPsychosis #PostpartumMentalHealth #MaternalMentalHealth #WomensHealth #BipolarDisorder #PerinatalMentalHealth #PostpartumDepression

Pregnancy creates one of the biggest hormonal shifts the human body experiences. Estrogen and progesterone rise dramatically during pregnancy, then drop rapidly after delivery when the placenta is gone.

So what happens when the brain has to adapt to that sudden change?

In this episode, we take a closer look at postpartum depression and the connection between progesterone, allopregnanolone, GABA, and the brain. We also talk about why postpartum depression is not simply a matter of having “low hormones” and why some women may be more sensitive to reproductive hormone changes than others.

In this episode, we break down:

• How postpartum depression differs from the baby blues and postpartum psychosis
• What happens to estrogen, progesterone, and allopregnanolone after delivery
• How the GABA A receptor may be involved in the brain’s response to hormonal changes
• Why postpartum depression probably has multiple biological and environmental contributors
• Why simply giving progesterone is not as straightforward as it might seem
• What brexanolone and zuranolone do differently from traditional antidepressants
• Why bipolar screening is important before starting medication for postpartum depression or anxiety
• What future research could tell us about identifying women who are particularly sensitive to reproductive hormone withdrawal

Postpartum depression is real, common, treatable, and not a sign that a woman is weak or that she doesn’t love her baby.

The more we understand the biology behind postpartum depression, the more we can move away from asking whether a woman is depressed or whether her hormones are responsible and start asking how hormones, neurosteroids, neurotransmitters, genetics, sleep, stress, and other factors interact in a particular woman.

That shift could lead to much more targeted treatment for postpartum mental health.

Share this episode with a new mom or anyone who wants to better understand the biology behind postpartum depression.

Postpartum Depression | Postpartum Hormones | Progesterone | Allopregnanolone | GABA A Receptors | Postpartum Mental Health | Women’s Health | Hormone Health

#HumpDayHormones #PostpartumDepression #PostpartumMentalHealth #PostpartumHormones #Progesterone #WomensHealth #HormoneHealth #MaternalMentalHealth

Have you ever said, “I swear I become a completely different person the week before my period”?

Maybe you’re suddenly irritable, anxious, emotional, exhausted, unable to concentrate, or you just don’t want to be around anyone. Then your period starts, a few days pass, and you’re wondering what just happened.

That pattern matters.

In Season 2, Episode 84, we’re breaking down the difference between PMS, PMDD, and premenstrual exacerbation, or PME. We’re also diving into why PMDD is much more complicated than simply having “bad hormones.”

In this episode, we break down:

• The difference between common PMS symptoms and PMDD
• Why PMDD can occur even when reproductive hormone levels are completely normal
• What premenstrual exacerbation, or PME, is and why it can be missed
• How progesterone, allopregnanolone, and GABA may influence the brain
• Why a hormone panel cannot diagnose PMDD
• Why daily symptom tracking can be more useful than trying to remember how you felt last month
• Current treatment options, including SSRIs, hormonal contraception, lifestyle approaches, and emerging therapies
• What researchers are learning about the connection between reproductive hormones and women's mental health

One of the biggest takeaways from this episode is that your hormones may be completely normal, but your brain's response to those hormonal changes may not be.

If you feel like you become a completely different person every month, don't simply dismiss it as “being hormonal.” Track your symptoms, look for the pattern, and find someone who will listen.

And if symptoms ever become severe, especially if you're experiencing suicidal thoughts, PMDD deserves immediate medical and psychiatric attention.

Share this episode with a woman who has ever wondered why she feels completely different before her period.

PMS | PMDD | Premenstrual Dysphoric Disorder | Premenstrual Exacerbation | Hormone Health | Women's Mental Health | Progesterone | Menstrual Health

#HumpDayHormones #PMS #PMDD #WomensHealth #HormoneHealth #WomensMentalHealth #MenstrualHealth #Progesterone #HormoneHealth

For more than 20 years, women have often heard one of two messages about hormone therapy: that it is dangerous and should be avoided, or that it is the answer to everything. Neither tells the full story.

The research has changed, and menopause care has evolved. But not every headline on social media represents a true change in clinical practice.

In this episode, we look at what has changed over the past 10 years, five years, and especially the past year, and what those changes actually mean for women navigating menopause.

In this episode, we break down:

• Why hormone therapy should no longer be treated as one medication with one universal risk profile
• Why age, timing, dose, route, and type of hormone all matter when evaluating risks and benefits
• How our understanding of genitourinary syndrome of menopause and vaginal estrogen has changed
• What the evidence now says about vaginal estrogen for some breast cancer survivors
• Where testosterone actually fits into evidence based menopause care
• What has changed with compounded hormones, FDA warnings, and newer nonhormonal treatments for hot flashes
• Why modern menopause care is moving away from rigid age based rules and toward individualized, risk based treatment

We also talk about what hasn't changed. Hormone therapy is not a universal longevity drug, hormone levels alone should not diagnose perimenopause, systemic estrogen still requires appropriate endometrial protection when a woman has a uterus, and unexplained postmenopausal bleeding still needs evaluation.

The biggest shift isn't that hormones are completely safe or completely dangerous. It's that we're finally moving beyond treating hormone therapy as one drug with one risk profile.

The better question is: For this woman, for this indication, using this formulation, do the expected benefits outweigh the potential risks?

That's what evidence based, patient centered menopause care should look like.

Share this episode with a woman who has ever been told that hormone therapy is simply “good” or “bad.”

Menopause Care | Hormone Replacement Therapy | Hormone Therapy Research | Menopause Treatment | Vaginal Estrogen | Testosterone Therapy | Women's Health | Evidence Based Menopause Care

#HumpDayHormones #Menopause #HormoneReplacementTherapy #HormoneHealth #WomensHealth #MenopauseCare #VaginalEstrogen #TestosteroneTherapy #MenopauseResearch #HealthyAging

Progesterone can be incredibly helpful for some women. It can support sleep, calm the nervous system, regulate bleeding, and play an important role in hormone therapy. But for some women, taking progesterone can bring on anxiety, depression, fatigue, dizziness, brain fog, bloating, or that frustrating feeling of simply not feeling like themselves.

So what is actually happening?

In Episode 82, we’re diving into progesterone intolerance, why some women can have such a different response to the same hormone, and what options exist when oral micronized progesterone simply doesn’t work for you.

In this episode, we break down:

• What progesterone intolerance actually is and how it differs from progestin intolerance
• Why allopregnanolone and the GABA A receptor may play a role in how women respond to progesterone
• Why some women tolerate their own natural progesterone but struggle with oral progesterone
• How the timing, dose, and route of progesterone can change your experience
• What other options may provide endometrial protection when oral progesterone isn't tolerated
• Why progesterone creams may not provide adequate uterine protection
• How options like an IUD, different progestins, or Duavee may fit into the conversation

One of the biggest takeaways from this episode is that “I can’t tolerate progesterone” doesn’t mean the conversation is over. Your response to hormones is individual, and the goal is to find a safe, effective treatment plan that you can actually live with.

If progesterone has ever made you feel worse instead of better, this is an episode you’ll want to hear.

Share this with a woman who has ever wondered why progesterone makes her feel awful.

Progesterone Intolerance | Progesterone Therapy | Hormone Replacement Therapy | Menopause Care | Micronized Progesterone | Hormone Health | Perimenopause | Women's Health

#HumpDayHormones #Progesterone #ProgesteroneIntolerance #HormoneReplacementTherapy #Menopause #Perimenopause #HormoneHealth #WomensHealth #MicronizedProgesterone #MenopauseEducation

If you've been talking with friends about hormone therapy or scrolling social media lately, you've probably heard someone say they switched from estrogen pills to a patch.

It's not just a trend.

Recent prescription data shows estrogen patch use continues to rise, and there's a good reason why. As we've learned more about menopause medicine, we've also learned that how estrogen gets into your body matters.

In this episode, we break down:

• Why estrogen patches have become increasingly popular in menopause care
• How patches and pills work differently inside the body
• What current research says about blood clot risk and cardiovascular health
• Which women may benefit most from transdermal estrogen
• The pros and cons of patches, pills, and estrogen gels
• Common questions about absorption, dosing, and where to place your patch
• How to decide which form of hormone therapy may be right for you

The biggest takeaway? There isn't one "best" form of estrogen. The best choice depends on your health history, symptoms, lifestyle, and long term goals.

As always, we break down the latest research so you can have informed conversations with your healthcare provider and make decisions that are right for you.

Share this episode with a friend who's wondering whether an estrogen patch or pill is the better option.

Estrogen Patch | Hormone Replacement Therapy | Menopause Treatment | Estradiol Patch | Menopause Symptoms | Women's Health | Hormone Therapy | Transdermal Estrogen

#HumpDayHormones #Menopause #EstrogenPatch #HormoneReplacementTherapy #Estradiol #HormoneHealth #WomensHealth #MenopauseEducation #HealthyAging #TransdermalEstrogen

This week we're introducing the newest nurse practitioner at The Women's Clinic, Amy Wilson, APRN, and giving you the chance to get to know the person behind the provider.

With years of experience in women's health and specialized training in urogynecology, Amy shares why she dedicated her career to helping women feel heard, understood, and empowered through every stage of life.

In this episode, we discuss:

• Amy's journey into women's health and what led her to our practice
• Why so many women feel dismissed and how compassionate care can change that
• Common hormone myths and what every woman should know about hormone therapy
• What urogynecology is and when women should seek care for pelvic floor concerns
• The symptoms women often dismiss as "just aging" that deserve a closer look
• Amy's advice for women who are ready to take control of their health

Whether you're navigating menopause, hormone concerns, pelvic floor symptoms, or simply looking for a provider who truly listens, this episode is a chance to meet someone who's passionate about providing personalized, evidence based care.

We're thrilled to welcome Amy to the team and can't wait for you to get to know her.

Share this episode with someone who's looking for a women's health provider who truly listens.

Women's Health Provider | Hormone Therapy | Menopause Care | Urogynecology | Pelvic Floor Health | Hormone Optimization | Women's Wellness | Menopause Specialist

#HumpDayHormones #AmyWilson #WomensHealth #HormoneHealth #Menopause #Urogynecology #PelvicFloorHealth #HormoneTherapy #HealthyAging #WomensWellness

"Should your estradiol level be checked while you're on hormone therapy?"
"Or do your symptoms tell us everything we need to know?"

It's one of the biggest debates in menopause medicine.

Some providers say blood levels don't matter. Others want to see your estradiol above a certain number. So... who's right?

In this episode, we unpack what the research actually says and explain why the answer depends on what you're trying to accomplish. While symptoms remain the best guide for relieving hot flashes and night sweats, optimizing long term health may be a different conversation.

In this episode, we break down:

• Why routine estradiol testing isn't recommended for every woman on hormone therapy
• What estradiol levels may tell us about bone health and osteoporosis prevention
• How estrogen supports cardiovascular health, healthy blood vessels, and cholesterol
• The connection between estradiol, insulin resistance, and metabolic health
• What we know, and don't yet know, about estrogen and brain health after menopause
• Why treating symptoms and optimizing long term health aren't always the same goal
• How to think about estradiol numbers without chasing a "perfect" lab value

The biggest takeaway? We don't treat lab numbers, we treat women. Hormone therapy should always be individualized, using both symptoms and the best available evidence to support long term health.

Share this episode with someone navigating menopause or a healthcare provider who wants to stay up to date on the evolving science of hormone therapy.

#HumpDayHormones #Menopause #Estradiol #HormoneReplacementTherapy #HormoneHealth #BoneHealth #HeartHealth #Women'sHealth #MenopauseEducation #HealthyAging

A new Penn Medicine study is making headlines after researchers found that women taking GLP-1 medications had about 30% lower odds of being diagnosed with breast cancer compared to similar women who were not taking these medications.

So what does that actually mean?

In this episode, we separate the headlines from the science and explain why researchers are excited, while also discussing what we still don't know.

In this episode, we break down:

• What the new Penn Medicine breast cancer study actually found
• Why a 30% lower risk does not mean 30 out of 100 women avoided breast cancer
• How obesity, insulin resistance, inflammation, and estrogen influence breast cancer risk
• The biologic reasons GLP-1 medications may help reduce cancer risk
• The important limitations of this research and why it does not prove cause and effect
• What these findings could mean for women with obesity, insulin resistance, or a family history of breast cancer

The most exciting part of this research isn't that we suddenly have a new breast cancer prevention drug. It's that improving metabolic health may impact far more than the number on the scale.

As always, we'll discuss what the evidence supports today, what questions remain unanswered, and where the research is headed next.

Share this with someone who's been seeing the headlines and wondering what they really mean.

#HumpDayHormones #GLP1 #BreastCancerResearch #Semaglutide #Tirzepatide #WomensHealth #HormoneHealth #MetabolicHealth #BreastCancerAwareness #MedicalResearch

After nearly 100 years, one of the most common hormone disorders affecting women has officially been renamed. Following a 14 year international effort involving more than 22,000 patients, researchers, and medical experts, Polycystic Ovary Syndrome (PCOS) is now being called Polyendocrine Metabolic Ovarian Syndrome (PMOS).

Why does that matter?

Because the new name finally reflects what science has been telling us for years, this is a whole body hormonal and metabolic condition, not simply an ovarian disorder.

In this episode, we break down:

• Why PCOS was officially renamed PMOS and what prompted the historic change
• What the new name tells us about hormones, insulin resistance, and metabolism
• Why up to 70% of women with PMOS remain undiagnosed
• The four different types of PMOS patients we commonly see in clinic
• The long term health risks that extend far beyond fertility and irregular periods
• Why treatment needs to focus on both hormone balance and metabolic health

One of the biggest takeaways from this episode is that you probably know someone living with PMOS, whether they realize it or not. The condition affects up to 1 in 7 women of reproductive age, making it one of the most common endocrine disorders in women.

Understanding the new name isn't just about changing terminology. It's about changing the conversation, improving diagnosis, reducing stigma, and helping women receive the care they deserve.

Share this with a friend because chances are... you have a friend with PMOS.

#HumpDayHormones #PMOS #PCOS #HormoneHealth #InsulinResistance #WomensHealth #MetabolicHealth #EndocrineHealth #HormoneEducation #WomensWellness

This week we're heading back to school, GLP-1 Summer School, to answer the questions we're getting asked every single day in clinic.

A few years ago, hardly anyone had heard of medications like Ozempic, Wegovy, Mounjaro, and Zepbound. Now they're everywhere. Some people think they're a miracle. Others think they're dangerous. Most women are simply trying to sort through the noise and understand what is actually true.

In this episode, we break down:

• How GLP-1 medications actually work in the body
• What realistic weight loss looks like with semaglutide and tirzepatide
• Why these medications are about much more than weight loss
• Whether you'll gain weight back after stopping and how to transition off successfully
• The truth about muscle loss, hair loss, and "Ozempic face"
• How GLP-1 therapy and hormone replacement therapy may work together
• What patients should know about compounded medications
• Why retatrutide is generating so much excitement for the future of obesity medicine
We also discuss one of the biggest misconceptions surrounding GLP-1 therapy: the idea that the medication is the entire treatment plan.

The medication may open the door, but long term success still depends on nutrition, muscle preservation, sleep, stress management, hormone health, and sustainable habits.

This conversation is designed to help you understand the science, separate fact from fiction, and make sense of one of the fastest moving areas in medicine today.

Share this with the friend who keeps texting you GLP-1 questions.

#HumpDayHormones #GLP1 #Semaglutide #Tirzepatide #Ozempic #Wegovy #Zepbound #Mounjaro #MetabolicHealth #WeightLossMedicine #HormoneHealth #WomensHealth

“Why does my skin suddenly feel dry, thin, sensitive, and impossible to manage?”
“Is it aging... or is it my hormones?”

This week we're joined by Susan Campbell, founder and CEO of Phosis Skincare, an award winning skincare brand created specifically for perimenopausal and menopausal women. Susan's innovative approach to skincare earned national recognition when Phosis was selected by Oprah Daily's Menopause O Awards, making her one of the leading voices in this rapidly growing space.

Many women notice changes in their skin long before they recognize other symptoms of perimenopause. Dryness, loss of firmness, increased sensitivity, and stubborn changes in skin texture are often some of the earliest signs that hormones are shifting.

In this episode, we break down:

• What actually happens to skin during perimenopause and menopause
• How declining estrogen impacts collagen, hydration, elasticity, and skin barrier function
• Why skin often becomes noticeably drier after 40
• The surprising connection between hormones and skin health
• How much collagen women lose during and after menopause
• Which skincare ingredients become more important during midlife
• Common misconceptions women have about aging skin
• Where skincare fits alongside hormones, supplements, and aesthetic treatments
• Why caring for menopausal skin requires a different approach

Susan also shares her incredible entrepreneurial journey, including:

• How she identified a major gap in the skincare industry
• The inspiration behind creating Phosis
• What it took to build a skincare company from the ground up
• The story behind being selected for Oprah Daily's Menopause O Awards
• What happened when Oprah's team discovered Phosis
• A behind the scenes look at a potential Shark Tank opportunity
• Advice for anyone sitting on a business idea they've been afraid to pursue

This conversation is about more than skincare.

It's about understanding that the changes women experience during perimenopause and menopause are real, biologically driven, and deserving of solutions designed specifically for them.

Because healthy aging isn't about chasing youth. It's about supporting your body through every stage of life.

Share this with the woman who's wondering why her skincare routine suddenly stopped working.

“Your progesterone is low.”
“But is low progesterone actually the problem... or is it a symptom of something deeper?”

This week we're joined by returning guest Meg Green, Registered Dietitian and Integrative & Functional Nutrition Certified Practitioner, for a deep dive into one of the most talked about hormones in women's health: progesterone.

From anxiety and insomnia to weight gain and PMS, progesterone gets blamed for almost everything online. But what does progesterone actually do, what causes it to decline, and how much of the conversation are we getting wrong?

In this episode, we break down:

• What progesterone actually does beyond fertility and pregnancy
• How progesterone impacts sleep, mood, anxiety, and brain function
• The relationship between progesterone and estrogen balance
• Why many women labeled with "estrogen dominance" may actually be dealing with ovulation issues or declining progesterone
• Common symptoms associated with low progesterone and what may be causing them
• Whether low progesterone truly causes weight gain
• Why some women notice weight changes after starting progesterone therapy
• The connection between stress, cortisol, inflammation, and progesterone production
• How sleep deprivation, under eating, over exercising, and blood sugar swings can affect ovulation
• What low progesterone looks like in younger women, postpartum women, and women in perimenopause
• The role vitamin D and nutrition may play in hormone health
• Why symptoms matter just as much as lab values

Meg also helps us sort through some of the biggest myths surrounding progesterone, including whether stress can completely shut down progesterone production, whether regular cycles guarantee healthy progesterone levels, and whether every woman with anxiety in perimenopause needs progesterone.

This conversation is a reminder that progesterone may be part of the story, but it is rarely the whole story.

Because understanding why hormones change is often more important than focusing on a single number.

Share this with the woman who's been told low progesterone is the answer to everything.

#HumpDayHormones #Progesterone #HormoneHealth #WomensHealth #Perimenopause #FunctionalNutrition #MegGreen #HormoneBalance #WomensWellness

Are you exhausted but wired, waking at 3am, and wondering why your body feels out of sync?”
“What if it is not just stress, but a full hormone and cortisol conversation your body is trying to have with you?”

We are joined by Christa Jackson, APRN at Beyond Wellness, a clinician deeply rooted in personalized, root cause hormone care and formerly with Cornerstone OB GYN alongside Dr Kay Chandler. In this conversation, we dive into what she is seeing every day in women who feel overwhelmed, dismissed, and physically off balance.

This episode unpacks what we are calling cortisol chaos, the intersection of chronic stress, hormone shifts, sleep disruption, and the realities of perimenopause that so many women are navigating at once.

In this episode, we break down:
• Why so many women feel anxious, fatigued, and unlike themselves during this stage of life
• What cortisol actually does in the body and why it is essential, not the enemy
• How chronic stress, sleep disruption, and blood sugar swings create a feedback loop
• Why estrogen plays a major role in stress resilience and emotional stability
• What changes in perimenopause that makes stress feel harder to recover from
• How cortisol interacts with thyroid function and energy regulation
• What clinicians are actually seeing in labs, symptoms, and real patient stories
• Lifestyle and hormonal strategies that support recovery instead of burnout

We also talk through what it looks like in real clinical practice when women feel terrible but are told everything looks normal, and how a different approach to hormones, sleep, and nervous system health can change everything.

This conversation is about more than cortisol. It is about understanding what your body is adapting to, and why it is not failing you, it is responding.

Share this with the woman who feels like her body is stuck in overdrive.

“Is the system failing women… or was it never built for us in the first place?”
“Why do so many women feel dismissed when they finally ask for help?”

Women make up over half the population, yet their symptoms, pain, and lived experiences are still too often minimized, delayed, or misunderstood in healthcare. In this episode, we dig into the uncomfortable truth behind inequity in women’s medicine and what starts to change when women finally start talking to each other.

This conversation is bigger than hormones. It’s about the entire system women are navigating.

In this episode, we break down:
• Why women’s symptoms are more likely to be dismissed or misattributed
• The historical exclusion of women from medical research and clinical trials
• How outdated diagnostic models still shape modern care
• Why conditions like endometriosis, autoimmune disease, and heart disease are so often missed or delayed
• What current research actually shows about gender bias in diagnosis and treatment
• How social media and online communities are changing patient advocacy

We also sit down with Claire Brown, founder of MOVE Realty and creator of the Little Rock Power Women’s community, which has grown into a space where over 30,000 women share real healthcare experiences, support each other, and call out gaps in care.

Claire shares:
• Why she started the Power Women community
• What women are really searching for when they join
• The most common patterns she sees in shared healthcare experiences
• How community changes the way women advocate for themselves
• Whether online conversations are creating awareness or real change

A few realities that frame this conversation:
• Women account for about 75% of autoimmune cases
• They are 5 to 8 times more likely to experience thyroid disorders
• Around 80% of osteoporosis cases occur in women
• Depression and anxiety are diagnosed nearly twice as often in women
• Women are more likely to experience delayed diagnosis across 100+ diseases
• Studies show women often wait longer, receive less pain medication, and are more likely to be misdiagnosed, especially in emergency and cardiac care
• One study found 93% of women reported feeling dismissed when seeking medical help

And this isn’t random. It’s systemic:
Women were historically excluded from research, underrepresented in clinical trials until the 1990s, and often studied through male centered models of disease. Even today, symptoms like fatigue, pain, and hormonal changes are still frequently minimized or attributed to stress or anxiety.

But here is what matters most.

When women compare experiences, patterns emerge.
And when patterns emerge, silence breaks.

This episode is about that shift.

Because being told “everything looks normal” should not be the end of the conversation.

Practical takeaways:
• Track your symptoms and patterns over time
• Ask follow up questions when something feels off
• Seek second opinions when needed
• Do not accept dismissal as diagnosis
• Find providers who listen beyond lab results
• Trust your lived experience as data, not emotion

Share this with the woman who has ever been told “it’s all in your head.”

New Episode of Hump Day Hormones is LIVE!

“If testosterone works so well, why isn’t it approved?”
“Is it not safe, or is there something else going on?”

If you’ve ever questioned why testosterone for women is still considered “off-label,” this episode is for you. This is not a simple answer, and it has a lot less to do with effectiveness than most people think.

In this episode, we break down:

• The difference between clinical guidelines and FDA approval
• Why lack of pharmaceutical incentive stalled large-scale trials
• The real safety concerns regulators wanted answered
• Why long-term data is still limited
• Why measuring sexual desire makes trials more complex
• How dosing and product design complicate standardization

We also walk through what actually happened historically. Testosterone has been approved for men for decades and is even used in other countries for women, but in the U.S., timing, funding, and regulation all collided, especially after the Women’s Health Initiative, slowing research and halting momentum.

When companies tried to bring female-specific products to market, they did not fail because they didn’t work. They ran out of time, funding, or both.

Here’s the reality:

The FDA approves products, not hormones, and without the right funding, formulation, and long-term data, approval never happened.

So instead, we are left with off-label prescribing, compounded options, and inconsistent dosing, not because testosterone doesn’t work, but because the system never fully supported bringing it to market for women.

This episode also breaks down what testosterone is actually proven to help with, what is still emerging, and what it is not meant to be used for, so you can understand where it fits and where it doesn’t.

Share this with the woman who’s been told, “If it worked, it would already be approved.”

“Does testosterone increase cancer risk?”
“Is it safe for my heart?”
“Will it make me gain weight?”

This is the episode where we take the most common fears around testosterone and go straight to the data.

Because there is a lot of confusion, and a lot of misinformation.

In this episode, we break down:

❤️ What current research shows about cardiovascular risk in physiologic dosing
🫀 Lipids, blood pressure, and metabolic markers in clinical trials
🎗️ What studies actually show about breast cancer risk and mammographic density
🧬 The difference between androgen receptor effects vs estrogen conversion in breast tissue
⚖️ Why dose and tissue context completely change outcomes
💪 How testosterone affects muscle mass, fat distribution, and insulin sensitivity
📉 What we know about body composition changes in women on therapy

We also talk about one of the most important distinctions:

Physiologic dosing is not the same as supraphysiologic exposure.

Most side effects and risks seen in practice are related to dosing, not the hormone itself.

And when used appropriately, the data we have so far does not show increased short-term risk for cardiovascular disease or breast cancer in women studied.

But we are also honest about the limitations:

Most trials are short term, and long-term data is still evolving.

Finally, we cover weight and metabolism:

Testosterone is not a weight loss drug.
But it does play a meaningful role in:

Lean muscle mass
Insulin sensitivity
Energy and activity levels

Which can indirectly support healthier body composition over time.

This episode is about clarity, not fear.

And helping you understand what the science actually says versus what people assume.