ICU Ed and Todd-Cast

Episode 104! In this episode we talk about VASSPR or vasopressin timing in septic shock published in JAMA by Peltan et al 2026! Only one article for the next few episodes as we step into a busy period with travel and service time.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/42872917/
JAMA: https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2026.21333

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If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 103 LIVE from CHEST in Phoenix. It was a wonderful conference and thanks for everyone who came and joined us! In this episode we talk about lung recruitment during sigh breaths and GLP-1 use and its association with mortality in septic shock! Thanks also to special guest Hayley Gershengorn and congrats to both Todd and Hayley for winning big awards at the CHEST conference!

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 102! In this episode we talk about ECMO anticoagulation strategies with RATE and go back in time to talk about the original landmark trial for ECMO in CESAR

RATE: https://pubmed.ncbi.nlm.nih.gov/42413523/
CESAR: https://pubmed.ncbi.nlm.nih.gov/19762075/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 101! In this episode we talk about targeted temperature management starting with TTM2 to set the stage and moving towards ICECAP published by Muerer et al in JAMA August 2026!

TTM2: https://pubmed.ncbi.nlm.nih.gov/34133859/
ICECAP: https://pubmed.ncbi.nlm.nih.gov/42554995/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 100! Can't believe we made it here. 100 episode of trying to fit into Todd's triple booked schedule. This episode we do a little reminiscing about the past 3 years of podcasting but not after talking about a trial published in the form of a research letter about olanzapine versus dexmedetomidine for delirium by Liu et al published in the Blue Journal May 2026

Olanzapine vs Dex: https://pubmed.ncbi.nlm.nih.gov/42118124/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 99! In this episode we talk about Nutrition and Exercise in Critical Illness published in AJRCCM June 2026 by Needham et al. A shorter episode today as we're dealing with end-of-summer travel schedules so we add a mailbag segment to this one.

NEXIS: https://pubmed.ncbi.nlm.nih.gov/42438140/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 98! We talk about polymyxin B filtration of endotoxin for patients with septic shock in EUPHRATES which sets the stage for Tigris. We also butcher Mesopotamian history (sorry!)

EUPHRATES: https://pubmed.ncbi.nlm.nih.gov/30304428/
Tigris:https://pubmed.ncbi.nlm.nih.gov/41887242/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 97! In this episode we talk about mucolytics for patients with difficult to clear secretions on the ventilator and the effects of a tele ICU rehabilitation intervention! We also have some emails following up on scurvy and the taste of chalk.

Scurvy History:https://pmc.ncbi.nlm.nih.gov/articles/PMC1276007/
Bootcamp: https://www.vumc.org/advanced-practice-critical-care/welcome
MARCH: https://www.nejm.org/doi/pdf/10.1056/NEJMoa2603406
Tele-Rehab: https://jamanetwork.com/journals/jama/article-abstract/2850403

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 96. In this episode we talk about ARISE FLUIDS (early pressors vs early fluids) and VICTORY (high dose Vitamin C in severe burn) both simultaneously presented and published at the CCR26 conference. Then we start digging out form our ever growing mailbag

ARISE-FLUIDS: https://pubmed.ncbi.nlm.nih.gov/42274006/

VICTORY: https://pubmed.ncbi.nlm.nih.gov/42267875/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 95! In this episode we talk about "Sodium Bicarbonate for In-Hospital Cardiac Arrest" by Granfeldt et al and "Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock" published by the ANZICS group both presented at the CCR26 conference.

BiHCA: https://pubmed.ncbi.nlm.nih.gov/42273960/
BiHCA: https://jamanetwork.com/journals/jama/article-abstract/2850405
SODa-BIC: https://pubmed.ncbi.nlm.nih.gov/42283370/
SODa-BIC: https://www.nejm.org/doi/10.1056/NEJMoa2600526

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 94! In this episode we give some general reactions to the CCR conference, discuss our impact on the critical care world, and talk briefly about 3 of the presentations from the conference that did NOT have a simultaneous publication (REMAP-CAP oseltamivir, FISSH, and SAVE-ICU)

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 93! In this episode we go over TOWAR or "Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage" by Sperry et all published in NEJM and "Remote Multicomponent Rehabilitation in Intensive Care Unit Survivors" published by O'Neill et al in JAMA both in May 2026 and presented at the ATS International Conference! Then we talk a little bit about some current events with Hantavirus and sepsis that has hit the news cycles

TOWAR (NEJM): https://www.nejm.org/doi/full/10.1056/NEJMoa2602167
iRehab (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2849320

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 92! In this episode we talk about "Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients" published in JAMA by Sonneville et al April 2026!

R2D2 (pubmed): https://pubmed.ncbi.nlm.nih.gov/41841304/

R2D2 (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2846726

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 91! In this episode we talk about "Dexmedetomidine for treatment of hyperactive delirium in non-intubated ICU patients" published by Godet et al in Intensive Care Medicine October of 2025! We are going to be on a one article per episode kick for a while but hope to get back to normal programming soon!

4D: https://pubmed.ncbi.nlm.nih.gov/41160116/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 90! In this episode we talk about the 2026 Surviving Sepsis Campaign Guidelines lead by Prescott et all and published in Critical Care Medicine in March of 2026! We review all that's new and all that's changed

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 89! In this episode we talk about HI-PEITHO or catheter directed thrombolysis versus conventional anticoagulation for intermediate risk pulmonary embolism. This was published in the New England Journal of Medicine by Rosenfield et al.

HI-PEITHO: http://nejm.org/doi/full/10.1056/NEJMoa2516567

HI-PEITHO (pubmed): https://pubmed.ncbi.nlm.nih.gov/41910345/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episodes 88! In this episode we talk about guidelines recently released for the management of pulmonary embolism and cardiac arrest! A little hap hazard of an episode as we jump around from topic to topic but good to highlight things that are new and things that are changing!

PE: https://pubmed.ncbi.nlm.nih.gov/41712898/

CPR: https://pubmed.ncbi.nlm.nih.gov/41122893/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 87! In this episode we talk about Albumin with two related studies, ALBIOS ("Albumin replacement in patients with severe sepsis or septic shock" by Caironi et al) and ARISS ("Albumin Replacement Therapy in Septic Shock" by Sakr et al)

ALBIOS: https://pubmed.ncbi.nlm.nih.gov/24635772/

ARISS: https://pubmed.ncbi.nlm.nih.gov/41712212/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 86! In this episode we talk about endotracheal tubes or "Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation" published in Lancet Respiratory Medicine February 2026 by Treggiari et al.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/41319662/

LRM: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00294-2/abstract

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 85! In this episode we go over LIBERATE-D or "A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury" by Liu et al in JAMA 2026. We have the second author, Eddie Siew, on with us to discuss!

LIBERATE-D (pubmed): https://pubmed.ncbi.nlm.nih.gov/41201895/

LIBERATE-D (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2841171

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!