Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

Does your histamine bucket feel like it’s overflowing? In this replay of one of the Histamine Well Podcast’s fourth most popular episodes, Joanne explores her approach to managing histamine symptoms while investigating the underlying causes.

If you’re navigating histamine intolerance and symptoms such as headaches, hives, bloating or disrupted sleep, this episode explores dietary strategies and supplement considerations to discuss with your practitioner. Joanne also explains why individual responses matter, particularly when supplements seem to make symptoms worse.

In this episode, Joanne discusses:

• A low histamine diet as a short-term strategy while addressing underlying causes.
• DAO enzymes and their role in breaking down histamine in food.
• Supplement considerations, including quercetin, vitamin C and Saccharomyces boulardii.
• The connection between SIBO, histamine symptoms and dietary choices.
• Why constipation, digestion and gut motility deserve attention.
• Oxalate sensitivity and why further dietary restrictions need individual guidance.
• How oestrogen, progesterone and hormonal changes may influence symptoms.
• Methylation and why methylated B vitamins may not suit everyone.

Whether you’re new to histamine intolerance or revisiting the foundations, this episode offers insight into Joanne’s clinical approach and questions to explore with your healthcare practitioner.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

When is the best time to take L-theanine—for daytime anxiety, before bed, or when you wake during the night?

In this short Q&A episode of The Histamine Well Podcast, Joanne discusses how she uses L-theanine to support relaxation and explains how timing may differ depending on your symptoms. She also explores combining L-theanine with magnesium and the options she discusses when magnesium glycinate isn’t tolerated.

In this episode, you’ll learn:

• How Joanne uses L-theanine for daytime anxiety and nervous system hyperarousal.
• When she considers taking it before bed for difficulty falling asleep.
• How she approaches L-theanine timing for waking during the night.
• The doses and supplement combinations discussed in her clinical approach.
• Why individual tolerance matters when choosing magnesium.

If you’ve been wondering when to take L-theanine for anxiety or sleep, this quick episode explores the timing options Joanne considers in practice.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Bloating, constipation, and food reactions after food poisoning—could SIBO be part of the picture?

In this episode of The Histamine Well Podcast, Joanne walks through a real patient case of small intestinal bacterial overgrowth (SIBO), exploring persistent digestive symptoms, a methane-positive breath test, and suspected histamine-related reactions.

The patient had experienced significant bloating, nausea, reflux, constipation and brain fog, with probiotics making her bloating worse. Despite seeing several practitioners, she had not been assessed for SIBO.

Joanne shares the clues that prompted testing, why she prioritised a SIBO breath test over stool microbiome testing in this case, and how she introduced a SIBO low-histamine diet and personalised digestive support.

At her first follow-up, the patient reported an 80% reduction in bloating, alongside improvements in nausea, reflux and heartburn. With constipation still an issue, Joanne explains the next adjustments to her care and why retesting remained part of the plan.

In this episode, you’ll hear:

• The patient’s symptom history following food poisoning.
• Joanne’s reasoning behind targeted SIBO testing.
• How the methane-positive result informed her approach to constipation.
• The dietary changes and digestive support used initially.
• How Joanne adjusted the plan as symptoms improved.
• Her plans for follow-up, retesting and food reintroduction.

Whether you’re experiencing ongoing gut symptoms or supporting patients in clinical practice, this episode offers a practical look at Joanne’s assessment and treatment decisions.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Have you noticed low mood or sadness after taking calcium D-glucarate? If you’re using it to support oestrogen detoxification or address high beta-glucuronidase on a gut test, your stage of life and hormone levels deserve consideration.

In this short Q&A episode of The Histamine Well, Joanne explores why calcium D-glucarate may not suit everyone, particularly during perimenopause and menopause. She discusses the potential connection between oestrogen clearance and mood, and shares her own experience of feeling unusually sad while taking the supplement.

If a supplement leaves you feeling worse, that experience deserves attention. Listen to hear why Joanne encourages a closer look at your hormones, symptoms and treatment plan.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Could your gut help explain why you’re reacting to foods you once tolerated?

In this episode of The Histamine Well, Joanne explores the connection between gut health and histamine intolerance, explaining how the microbiome, intestinal lining, immune system, and nervous system interact.

A low histamine diet may help reduce symptoms, but what happens when the gut itself is contributing to your histamine burden? Joanne discusses SIBO, dysbiosis, histamine-producing bacteria, mast cells, and the DAO enzyme—and why understanding the underlying contributors matters.

What you’ll learn:

• How the intestinal barrier and secretory IgA help protect your gut.
• Why microbial diversity, butyrate and immune tolerance matter.
• How SIBO, dysbiosis and intestinal inflammation may contribute to histamine symptoms.
• How mast cells and certain gut bacteria produce histamine.
• Why intestinal health matters for DAO, the enzyme that helps break down dietary histamine.
• How stress, the nervous system, and gut motility can influence digestive symptoms.
• Why gut support needs to be personalised to your symptoms and tolerance.

Whether you’re navigating histamine intolerance yourself or supporting patients in clinical practice, this episode offers a clearer understanding of the gut–immune connection.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

A low FODMAP diet is often used to reduce bloating, so why might your symptoms get worse after starting one?

In this short Q&A episode, Joanne explores three possibilities: eating more sulfur-rich foods, replacing wheat with higher-oxalate ingredients, and changes in gut motility, including the migrating motor complex. She explains why it’s worth looking at what has changed in your diet instead of simply pushing through worsening bloating.

In this episode:

• How food swaps on a low FODMAP diet may increase your sulfur or oxalate intake
• Symptoms Joanne suggests watching for alongside bloating
• Why the migrating motor complex may matter when bloating persists
• Why a SIBO test can help clarify what may be going on

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well, Joanne is joined by clinical nutritionist Melanie Peers to explore circadian rhythm: the daily cycle that helps coordinate sleep, energy, hormones, digestion and immune activity. They also discuss why histamine symptoms may feel worse at certain times of the day or night.

Joanne and Melanie talk about the signals that can disrupt your body clock, from spending the day indoors to bright lights, screens and late meals at night. They share practical ways to support a more consistent rhythm, including morning daylight, time outdoors during the day and a darker evening routine.

In this episode, you’ll learn:

• What circadian rhythm is and why it matters beyond sleep
• How light and darkness influence cortisol and melatonin
• Why meal timing may matter for digestion and gut motility
• How histamine activity follows a daily pattern
• Simple ways to support your body clock within your routine

If you’re navigating histamine intolerance, sleep difficulties, hormone concerns or persistent gut symptoms, this conversation offers another piece of the picture to discuss with your healthcare practitioner.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

NAC can support glutathione production, respiratory health and biofilm disruption—but some people experience nausea, headaches, brain fog, fatigue or bloating after taking it.

In this Q&A episode, Joanne explains how reactions to NAC may be connected to sulfur intolerance, hydrogen sulfide production, gut dysbiosis, biofilm disruption and sensitivity to its mucolytic effects.

You’ll also learn why feeling worse doesn’t necessarily mean NAC is working—and why a lower dose, slower introduction or different approach may be needed.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Why do SIBO, Candida, and other gut infections sometimes return—even after treatment initially seems successful?

In this episode of The Histamine Well Podcast, Joanne explains how biofilms may contribute to persistent bacterial and fungal overgrowths. Biofilms are organised microbial communities surrounded by a protective matrix that can help microorganisms survive antimicrobial treatment and resist immune defences.

Joanne explores the role biofilms may play in recurring SIBO, Candida overgrowth, gut dysbiosis, chronic sinus infections and MARCoNS. She also explains how bacteria and fungi can communicate, share resources and coexist within mixed-species biofilms.

You’ll discover:

• What biofilms are and why microorganisms create them
• Why SIBO, Candida and gut infections may keep returning
• How biofilms can protect bacteria and fungi
• The connection between biofilms, chronic sinus infections and MARCoNS
• How Candida and Aspergillus form fungal biofilms
• The difference between mould, mycotoxins and biofilms
• What the biofilm matrix is made from
• How enzymes and N-acetylcysteine may support biofilm disruption
• Why biofilm support should be introduced gradually during antimicrobial treatment

If you’re dealing with recurring digestive symptoms or want to better understand persistent microbial overgrowths, this episode offers a clear and practical introduction to biofilms and their potential role in gut and sinus health.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Do you feel nauseous, dizzy, exhausted, or brain foggy after an Epsom salt bath? If a bath you hoped would help you relax leaves you feeling worse, you might wonder whether you’re experiencing a “detox reaction,” reacting to the heat or struggling to tolerate the Epsom salts themselves.

In this short Q&A episode of The Histamine Well Podcast, Joanne explores possible reasons for feeling sick after an Epsom salt bath, including bath temperature, changes in blood pressure, histamine intolerance, mast cell activation and sensitivity to sulfur compounds.

Epsom salts are magnesium sulfate. Joanne explains the role of sulfate in a detoxification pathway called sulfation and discusses why people use Epsom salt baths as part of their detox routines. She also shares why feeling unwell afterwards should not automatically be interpreted as a sign that a treatment is working—or a reason to push through.

If you’ve been searching for answers about Epsom salt bath side effects, feeling dizzy after a hot bath, or the possible connection between histamine intolerance and Epsom salts, this episode offers a starting point for understanding your reaction and discussing it with your practitioner.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Do eggs, garlic, onions or broccoli leave you feeling bloated, fatigued or foggy-headed?

In episode 57 of The Histamine Well Podcast, Joanne explores hydrogen sulfide SIBO and intestinal sulfide overproduction (ISO), discussing how sulfur-producing gut bacteria may contribute to these symptoms.

Discover:

• The connection between sulfur intolerance and the gut microbiome.
• Why hydrogen sulfide production and clearance both matter.
• The uses and limitations of stool and breath testing.
• Joanne’s clinical approach to low sulfur diets, oregano, molybdenum and digestive support.

Joanne also discusses where the evidence remains limited and why symptoms alone cannot confirm the cause.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Struggling with constipation on the low-FODMAP diet? If your bloating has improved but your bowel movements have slowed down, what should you consider next?

In this short Q&A episode of The Histamine Well Podcast, naturopath Joanne Kennedy shares how she approaches constipation in patients following a low-FODMAP diet. She discusses fibre intake, hydration, digestive support, and the role of the nervous system in bowel regularity.

If you’re navigating constipation, SIBO, bloating or histamine intolerance, this episode offers practical topics to discuss with your treating practitioner.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Can an imbalanced gut microbiome contribute to anxiety and depression?

We often think of mental health conditions as beginning solely in the brain. However, growing research suggests that the gut microbiome may also influence mood through the gut–brain axis.

In this episode of The Histamine Well, Joanne explores what gut dysbiosis is and how the gut communicates with the brain through the vagus nerve, immune signalling, inflammation, stress hormones, short-chain fatty acids and neurotransmitter precursors.

Joanne also examines what the research actually says about probiotics, intestinal permeability, depression and anxiety—without overstating the evidence or promising a simple cure.

In this episode, you’ll learn:

• What gut dysbiosis means and what can disrupt the gut microbiome
• How the vagus nerve connects the gut and brain
• Why short-chain fatty acids are important for inflammation and brain health
• How gut bacteria may influence the stress response and serotonin production
• What studies have found about the microbiome and depressive symptoms
• Why the evidence for depression is currently stronger than the evidence for anxiety
• What “psychobiotics” are and why probiotic benefits are strain-specific
• Why gut health interventions should complement—not replace—appropriate mental health treatment
• Practical ways to support microbial diversity and the gut–brain axis
• Why fermented foods and some prebiotic fibres may not suit everyone with histamine intolerance or SIBO

The science supports a genuine connection between gut health and mental health, but the relationship is complex. There is no single probiotic, diet or supplement proven to resolve anxiety or depression on its own.

Supporting the gut through a diverse, fibre-rich diet, appropriate prebiotic or fermented foods, regular movement, sufficient sleep and stress management may form one valuable part of a broader approach to mental wellbeing.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Could sluggish bile be affecting your digestion, gut health and histamine symptoms?

In this episode of The Histamine Well Podcast, Joanne Kennedy explains the essential role bile plays in fat digestion, nutrient absorption, liver detoxification and microbial balance. She also explores how poor bile flow may contribute to SIBO, histamine intolerance and increased oxalate absorption.

Joanne breaks down four popular bile-support supplements—ox bile, TUDCA, taurine and phosphatidylcholine—including how each works, when it may be considered and why they are not interchangeable.

In This Episode, You’ll Learn:

• Common symptoms of sluggish or inadequate bile flow
• What happens to digestion after gallbladder removal
• How poor bile flow may contribute to SIBO and histamine intolerance
• The connection between fat malabsorption and oxalates
• How ox bile supports fat digestion
• How TUDCA supports liver health and bile flow
• Why taurine is needed to produce functional bile salts
• How phosphatidylcholine supports bile quality and methylation
• Important supplement precautions involving gallstones and bile duct obstruction

Listen now to understand how bile affects digestion—and how targeted support may benefit your liver, gallbladder and gut health.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well, Joanne explores the powerful connection between stress, cortisol, mast cell activation, and histamine intolerance. She explains how chronic stress can keep the nervous system trapped in fight-or-flight mode, trigger histamine release, and contribute to symptoms such as itching, flushing, headaches, sinus congestion, digestive issues, and skin reactions.

You’ll learn how the HPA axis responds to stress, why cortisol is helpful in the short term, and what can happen when the body becomes less responsive to cortisol’s anti-inflammatory effects. Joanne also discusses how reduced vagal tone may affect inflammation, mast cell reactivity, and the body’s ability to return to a calm, regulated state.

In this episode, you’ll discover:

• How stress activates the HPA axis and sympathetic nervous system
• The connection between cortisol, mast cells, and histamine
• Why chronic stress may worsen histamine intolerance and MCAS symptoms
• How stress-signalling molecules can trigger histamine release
• What glucocorticoid resistance is and how it may affect inflammation
• The role of the vagus nerve in immune and nervous-system regulation
• Why antihistamines may not address the upstream cause
• Practical ways to improve vagal tone and support nervous-system regulation

Joanne also shares simple strategies to help the body shift from fight-or-flight into rest-and-repair mode, including breathwork, humming, singing, gentle neck massage, and other vagus nerve exercises.

If your histamine symptoms seem to flare during periods of stress, this episode will help you understand why—and what you can do to begin breaking the stress–histamine cycle.

Resources mentioned:

• The Secret Language of the Body
• The Workout Witch nervous-system programs

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Could oxalates be the hidden reason your histamine intolerance symptoms aren’t improving?

In this popular podcast replay, Joanne is joined by Melanie Peers to explore the often-overlooked connection between oxalates, histamine intolerance, inflammation, gut health, and nervous system dysregulation.

Oxalates are naturally occurring compounds found in many foods—including some commonly considered healthy. For sensitive individuals, a high oxalate load may contribute to pain, digestive problems, urinary symptoms, fatigue, and increased reactions to foods and supplements.

In this episode, Joanne and Melanie discuss:

• What oxalates are and how they can affect the body
• The connection between oxalates, histamine, and inflammation
• Common high-oxalate foods that may be contributing to symptoms
• Signs and symptoms associated with oxalate overload
• How gut health may influence oxalate absorption
• The impact of oxalates on minerals, sulfur, and important detoxification pathways
• Why some people develop multiple food and supplement intolerances
• The role of methylation and transsulfuration pathways
• Why nervous system regulation is an important part of recovery
• Why oxalates should be reduced carefully rather than eliminated too quickly

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

What is histamine, and why does it cause so many frustrating symptoms?

In this replay of one of our most popular episodes, Joanne explains the science of histamine intolerance in a simple, practical way. Learn how histamine affects your immune system, gut health, hormones, brain, and skin, why histamine levels become too high, and the common symptoms of histamine intolerance—including migraines, anxiety, insomnia, hives, eczema, reflux, bloating, and more.

Discover why a low-histamine diet alone isn't enough and why identifying the root cause is the key to lasting relief.

Whether you're new to histamine intolerance or revisiting this episode, this is the perfect place to start your healing journey.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

One of our most downloaded episodes is back.

If you've been diagnosed with histamine intolerance, MCAS, or unexplained food sensitivities, this replay is one you won't want to miss.

In this listener-favorite episode, Joanne Kennedy explains why histamine intolerance is not a diagnosis—it's a symptom of deeper underlying health issues. While many people rely on a low histamine diet to manage symptoms, lasting improvement comes from identifying and treating the root causes driving excess histamine production.

Drawing on years of clinical experience, Joanne walks through the most common contributors to histamine intolerance, including SIBO, gut dysbiosis, leaky gut, digestive enzyme insufficiency, mold illness, oxalates, methylation issues, hormonal imbalances, and chronic inflammation.

Whether you're a practitioner, student, or someone struggling with chronic histamine symptoms, this episode will help you better understand why histamine intolerance develops—and where to start looking for answers.

Listen, Learn & Share

If this episode helps you better understand your histamine symptoms, please follow The Histamine Well Podcast, leave a review, and share it with someone searching for answers.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Many people with flushing, hives, anxiety, brain fog, digestive issues, food sensitivities, and heart palpitations are told they have either histamine intolerance or Mast Cell Activation Syndrome (MCAS). While these conditions can look remarkably similar, they have very different underlying mechanisms—and understanding those differences is often the key to finding the right treatment.

In this episode, Joanne explains the difference between histamine intolerance and MCAS, why symptoms overlap, and why some people continue to react despite following a low histamine diet. Drawing on her clinical experience, Joanne explores how histamine is processed in the body, the role of DAO and HNMT enzymes, common triggers for mast cell activation, and why addressing the root cause is essential for long-term recovery.

She also discusses the connection between mould mycotoxins, gut dysfunction, SIBO, oxalates, nervous system dysregulation, and histamine-related illness, while sharing practical insights into how she approaches assessment and treatment in clinical practice.

In this episode, you'll learn:

• The difference between histamine intolerance and Mast Cell Activation Syndrome (MCAS)
• Why these conditions share many of the same symptoms but require different treatment approaches
• How DAO and HNMT enzymes help regulate histamine in the body
• Common causes of histamine intolerance, including gut dysfunction, SIBO, mould exposure, oxalates, and hormone imbalances
• Why MCAS symptoms are often more severe, unpredictable, and triggered by non-food factors
• The connection between mould mycotoxins, chronic inflammation, and mast cell activation
• Which laboratory tests may be helpful—and why some commonly recommended tests have limited clinical value
• Joanne's clinical approach to identifying and treating the root causes of histamine-related symptoms

Whether you're navigating histamine intolerance, suspect MCAS, or you're a healthcare practitioner wanting a deeper understanding of these complex conditions, this episode provides practical, evidence-informed insights to help you take the next step towards better health.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Many women enter their 40s expecting a few hormonal changes, but are often unprepared for the anxiety, sleep disturbances, fatigue, low mood, histamine symptoms, weight changes, and nervous system shifts that can accompany perimenopause.

In this episode, Joanne shares her clinical and personal experience working with women through perimenopause and menopause, including her own journey with bioidentical oestrogen and progesterone. She discusses the signs of low oestrogen and progesterone, the limitations of standard hormone testing, and how bioidentical hormone therapy may support women during this transition.

You'll learn:

• The difference between perimenopause and menopause
• Common symptoms of low oestrogen and low progesterone
• How hormonal changes can influence histamine intolerance and mast cell activation
• Why hormone blood tests don't always tell the full story
• The potential benefits and challenges of bioidentical oestrogen and progesterone
• The connection between hormones, anxiety, sleep, mood, energy, libido, and weight
• Why hormone therapy should be individualised rather than one-size-fits-all

Whether you're navigating perimenopause yourself or supporting women through this stage of life, this episode offers practical insights to help you better understand the relationship between hormones, histamine, and healthy ageing.

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.

🎓 Practitioner or student? Join the waitlist for theHistamine & Methylation Online Group Coaching Course starting early 2026!

📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!